The Role of Plasminogen Activation in Smooth Muscle Cell Migration after Arterial Injury

The migration of smooth muscle cells from the media to the intima that occurs after balloon catheter injury to the rat common carotid artery has been quantified by an electron microscopic surveying technique. These vessels have also been assayed for plasminogen-activator activity, which was found to...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1992-12, Vol.667 (1), p.141-150
Main Authors: JACKSON, CHRISTOPHER L., REIDY, MICHAEL A.
Format: Article
Language:English
Subjects:
Animals
Antihypertensive Agents - pharmacology
Carotid Arteries - drug effects
Carotid Arteries - physiology
Carotid Artery Injuries
Catheterization - adverse effects
Cell Movement - drug effects
Dipeptides - pharmacology
Fibrinolysin - biosynthesis
In Vitro Techniques
Kinetics
Lisinopril
Male
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - injuries
Muscle, Smooth, Vascular - physiology
Rats
Rats, Sprague-Dawley
Time Factors
Tissue Plasminogen Activator - metabolism
Tranexamic Acid - pharmacology
Urokinase-Type Plasminogen Activator - metabolism
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Summary:The migration of smooth muscle cells from the media to the intima that occurs after balloon catheter injury to the rat common carotid artery has been quantified by an electron microscopic surveying technique. These vessels have also been assayed for plasminogen-activator activity, which was found to rise sharply 4 days after balloon injury. At this time point smooth muscle cells begin to migrate in appreciable numbers. In order to investigate whether there is a causal relationship between plasminogen-activator activity and smooth muscle cell migration, animals were dosed with tranexamic acid. This synthetic inhibitor of plasmin activity reduced smooth muscle cell migration by 73% (p < 0.05), indicating that plasmin activity is necessary for migration after balloon injury. Lisinopril, an inhibitor of angiotensin-converting enzyme, inhibited smooth muscle cell migration after balloon injury by 78% (p < 0.01) but did not influence plasminogen-activator activity. Taken together, these results show that plasmin is a necessary but not sufficient component in the pathway that leads to smooth muscle cell migration after balloon catheter injury in the rat.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1992.tb51606.x