Normal serum concentrations of anti-Müllerian hormone in women with regular menstrual cycles

• Published in: Reproductive biomedicine online 2010-10, Vol.21 (4), p.463-469
• Main Authors: La Marca, A, Sighinolfi, G, Giulini, S, Traglia, M, Argento, C, Sala, C, Masciullo, C, Volpe, A, Toniolo, D
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aging; AMH; Anti-Mullerian Hormone - blood; Contraceptives, Oral - therapeutic use; Cross-Sectional Studies; European Continental Ancestry Group; Female; healthy women; Humans; Menstrual Cycle; Middle Aged; normal values; Obstetrics and Gynecology; ovarian reserve; Reference Values; reproductive period
• ISSN: 1472-6483; 1472-6491
• DOI: 10.1016/j.rbmo.2010.05.009

Abstract Anti-Müllerian hormone (AMH) has become the ‘molecule of the moment’ in the field of reproductive endocrinology. Indeed, it is valuable as a means of increasing understanding of ovarian pathophysiology and for guiding clinical management across a broad range of conditions. However, no normative values have been established for circulating AMH in healthy women. In this cross-sectional study, 277 healthy females (aged 18–50 years) were included. AMH was measured by commercial enzyme-linked immunosorbent assay. Serum AMH concentrations show a progressive decline with female ageing. The age-related changes in AMH were best fitted by a polynomial function. Mean AMH concentrations were not modified by past use of oral contraceptive and were independent of parity of women. Age-specific normative values for circulating AMH concentration were established. AMH concentrations seem to be independent of the reproductive history of the patient. Anti-Müllerian hormone (AMH) has become the ‘molecule of the moment’ in the field of reproductive endocrinology. Indeed, it is valuable as a means for increasing our understanding of ovarian pathophysiology, and for guiding clinical management across a broad range of conditions. However, no normative values have been established for circulating AMH in healthy women. In this cross-sectional study, 277 healthy females (aged 18–50) were included. AMH was measured by commercial enzyme-linked immunosorbent assay. Serum AMH concentrations show a progressive decline with female ageing. The age-related changes in AMH were best fitted by a polynomial function. Mean AMH concentrations were not modified by past use of oral contraceptive and were independent of parity of women. We established age-specific normative values for circulating AMH. AMH concentrations seem to be independent of the reproductive history of the patient.