Involvement of the central nervous system in renal hypertension

• Published in: European journal of pediatrics 1993, Vol.152 (1), p.59-63
• Main Authors: SCHÄRER, K, BENNINGER, C, HEIMAN, A, RASCHER, W
• Format: Article
• Language: English
• Subjects: Adolescent; Biological and medical sciences; Blood Pressure; Central Nervous System Diseases - epidemiology; Central Nervous System Diseases - etiology; Central Nervous System Diseases - physiopathology; Child; Child, Preschool; Humans; Hypertension, Renal - complications; Infant; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - mortality; Medical sciences; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; Renovascular diseases; Retrospective Studies
• ISSN: 0340-6199; 1432-1076
• DOI: 10.1007/BF02072518

Involvement of the central nervous system (CNS) is a major complication of renal hypertension and is usually due to hypertensive encephalopathy. During a 17-year period we observed 25 children with renal hypertension associated with CNS manifestations in the absence of (group A) and 33 in the presence of advanced renal failure (group B). Convulsions were the most important symptom (65% in both groups combined). Other manifestations were reduced consciousness (69%), visual disturbances (28%), hemiplegia (14%), and cranial nerve palsy (10%). In 56% of children in group A, hypertension was recognised only after appearance of CNS symptoms. Three patients in group A and 19 in group B died. Intracranial haemorrhage associated with hemiplegia was found in 3 cases. From 1970-1977 to 1978-1986 the number of patients and the mortality in group B declined dramatically, probably as a result of improved antihypertensive and renal replacement therapy. In contrast, in group A the number of patients and of CNS symptoms remained similar. The study underlines the importance of frequent blood pressure monitoring in presence of acute or chronic renal disease.