Non‐A, non‐B posttransfusion hepatitis: Comparing C and non‐C hepatitis

Using assays to detect antibodies against antigens (C‐100, 5‐1‐1, C‐22 and C‐33) of the hepatitis C virus, we tested stored sera from 40 patients prospectively identified as having non‐A, non‐B posttransfusion hepatitis. The 28 patients who demonstrated seroconversion (“documented hepatitis C”) had...

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Published in:Hepatology (Baltimore, Md.) Md.), 1993-03, Vol.17 (3), p.361-365
Main Authors: Koretz, Ronald L., Brezina, Maria, Polito, Alan J., Quan, Stella, Wilber, Judith, Dinello, Robert, Gitnick, Gary
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Biological and medical sciences
Enzyme-Linked Immunosorbent Assay
Female
Hepacivirus - immunology
Hepatitis Antibodies - analysis
Hepatitis C - immunology
Hepatitis C - physiopathology
Hepatitis, Viral, Human - etiology
Hepatitis, Viral, Human - immunology
Hepatitis, Viral, Human - physiopathology
Human viral diseases
Humans
Immunoblotting
Infectious diseases
Male
Medical sciences
Middle Aged
Transfusion Reaction
Viral diseases
Viral hepatitis
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Summary:Using assays to detect antibodies against antigens (C‐100, 5‐1‐1, C‐22 and C‐33) of the hepatitis C virus, we tested stored sera from 40 patients prospectively identified as having non‐A, non‐B posttransfusion hepatitis. The 28 patients who demonstrated seroconversion (“documented hepatitis C”) had more severe initial disease; all 20 cases of chronic hepatitis occurred in this subgroup. Only 2 of the 12 patients who did not demonstrate such seroconversion even had symptoms. In the group of patients with documented hepatitis C, chronic hepatitis was more commonly seen in men (89%) than in women (40%). The patients in whom antibody to the C‐100 antigen developed were younger and had received more blood than had those patients who had hepatitis C diagnosed by demonstration of antibodies to the 5‐1‐1, C‐22 or C‐33 antigen (or all three). The proportion of cases of posttransfusion hepatitis that could be associated with antibody seroconversion decreased around the time that blood banks switched to an all‐volunteer system. The hepatitis seen in patients who failed to demonstrate serological evidence of hepatitis C virus exposure was usually clinically unimportant; it may or may not have been due to viral infection. (HEPATOLOGY 1993;17:361–365.)
ISSN:0270-9139
1527-3350
DOI:10.1002/hep.1840170303