Dissociation of Interference With the Speed and Accuracy of Escape Produced by Inescapable Shock

Benzodiazepines and naltrexone administered before inescapable shock block behavioral consequences of the inescapable shock such as poor shuttle box excape, reduced activity in reaction to shock, reduced social interaction, and so on. Anxiogenic β-carboline derivatives such as FG-7142 can produce th...

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Bibliographic Details
Published in:Behavioral neuroscience 1993-02, Vol.107 (1), p.139-146
Main Authors: Maier, Steven F, Minor, Thomas R
Format: Article
Language:English
Subjects:
Animal
Animals
Arousal - drug effects
Attention - drug effects
Behavior
Benzodiazepines
Biological and medical sciences
Carbolines - pharmacology
Chlordiazepoxide - pharmacology
Diazepam - pharmacology
Discrimination Learning - drug effects
Dose-Response Relationship, Drug
Drugs
Electroshock
Escape Conditioning
Escape Reaction - drug effects
Fear - drug effects
Fundamental and applied biological sciences. Psychology
Interference (Learning)
Learning
Learning. Memory
Naltrexone
Naltrexone - pharmacology
Orientation - drug effects
Problem Solving - drug effects
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Sprague-Dawley
Reaction Time
Reaction Time - drug effects
Receptors, GABA-A - drug effects
Restraint, Physical
Space life sciences
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Summary:Benzodiazepines and naltrexone administered before inescapable shock block behavioral consequences of the inescapable shock such as poor shuttle box excape, reduced activity in reaction to shock, reduced social interaction, and so on. Anxiogenic β-carboline derivatives such as FG-7142 can produce these effects by themselves. In the present study, neither diazepam nor naltrexone had any effect on the intereference with Y-maze choice escape accuracy produced by inescapable shock even though they both eliminated the reduction in Y-maze escape response speed produced by inescapable shock. Analogously, FG-1742 did not lead to a reduction in Y-maze choice escape response accuracy even though it did slow escape responding. These data imply that inescapable shock intereferes with escape choice learning and escape response speed by different mechanisms, the former not involving fear-anxiety processes.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.107.1.139