Osteogenic activity of β-tricalcium phosphate in a hydroxyl sulphate matrix and demineralized bone matrix: a histological study in rabbit mandible

Currently, in oral and maxillofacial surgery, there is a clinical need for efficient bone grafting materials, and various efforts are being made to improve materials used as bone substitutes to facilitate faster and denser bone regeneration. The purpose of this study was to evaluate in vivo the oste...

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Published in:Journal of Oral Science 2010, Vol.52(3), pp.377-384
Main Authors: Eleftheriadis, Efstathios, Leventis, Minas D., Tosios, Konstantinos I., Faratzis, Gregory, Titsinidis, Savvas, Eleftheriadi, Iro, Dontas, Ismini
Format: Article
Language:English
Subjects:
Animals
Bone Matrix - transplantation
Bone Regeneration - drug effects
Bone Substitutes - pharmacology
Calcium Phosphates - pharmacology
demineralized bone matrix
Dentistry
histology
Humans
Male
Mandible - surgery
osseous defects
Osteogenesis - drug effects
osteogenic grafting material
Rabbits
Random Allocation
synthetic β-tricalcium phosphate
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Summary:Currently, in oral and maxillofacial surgery, there is a clinical need for efficient bone grafting materials, and various efforts are being made to improve materials used as bone substitutes to facilitate faster and denser bone regeneration. The purpose of this study was to evaluate in vivo the osteogenic potential of synthetic β-tricalcium phosphate in a hydroxyl sulphate matrix (β-TCP/HS) and human demineralized bone matrix (DBM) putty. Sixteen New Zealand White rabbits were used. In each animal, two bone defects (8 mm length × 3 mm width × 3 mm depth) were created in the left and right regions of the mandible, respectively. The defect on one side, chosen randomly, was filled with β-TCP/HS (group A) or DBM putty (group B), while the defect on the opposite side was left unfilled in order to serve as a control site. Two animals in each group were sacrificed at the end of the 1st, 3rd, 5th and 6th week after surgery, respectively, and the osteotomy sites were processed for histological evaluation. Our findings confirmed that β-TCP/HS and human DBM putty possess osteogenic activity and can support new bone formation, although at a slower rate than the spontaneous healing response, in rabbit mandibular osseous defects. (J Oral Sci 52, 377-384, 2010)
ISSN:1343-4934
1880-4926
DOI:10.2334/josnusd.52.377