Photosensitizers as virucidal agents

The photosensitizer, benzoporphyrin derivative monoacid ring A (BPD-MA) has been studied regarding its ability to destroy enveloped viruses in blood and blood products when activated by light. Its maximum wavelength of absorption (690 nm) has proven useful in terms of activation of the photosensitiz...

Full description

Saved in:
Bibliographic Details
Published in:Journal of photochemistry and photobiology. B, Biology Biology, 1993-02, Vol.17 (2), p.99-108
Main Authors: NORTH, J, NEYNDORFF, H, LEVY, J. G
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - blood
Acquired Immunodeficiency Syndrome - drug therapy
Acquired Immunodeficiency Syndrome - immunology
AIDS/HIV
Animals
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
Biological and medical sciences
HIV
HIV Infections - blood
HIV Infections - drug therapy
HIV Infections - immunology
human immunodeficiency virus
Humans
Leukocytes - drug effects
Light
Medical sciences
Pharmacology. Drug treatments
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
Structure-Activity Relationship
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The photosensitizer, benzoporphyrin derivative monoacid ring A (BPD-MA) has been studied regarding its ability to destroy enveloped viruses in blood and blood products when activated by light. Its maximum wavelength of absorption (690 nm) has proven useful in terms of activation of the photosensitizer in materials containing red blood cells. Experiments conducted on whole blood of patients infected with the human immunodeficiency virus (HIV) demonstrated that BPD-MA and light could effectively eliminate the virus when treated materials were placed in culture and tested for viral p24, but did not appear to damage blood cells or blood components. Since HIV is largely intracellular in infected individuals, these results were investigated further. We have shown, using flow cytometry, that in HIV-infected blood, BPD-MA and light appear to selectively destroy white cells that bear the interleukin 2 receptor and the DR antigen. These markers are prevalent on activated lymphocytes, and since HIV replicates only in CD4+ T cells which are activated, this finding provides an explanation for the selective killing of HIV.
ISSN:1011-1344
DOI:10.1016/1011-1344(93)80002-Q