Stress protein synthesis and accumulation after traumatic injury of crayfish CNS

By several days after a crush injury of crayfish CNS, the wound site heals. Changes in protein synthesis and accumulation occur at the lesion site and nearby. During the first few hours, synthesis of 35, 70, 90, and 150 kDa proteins is induced in the injured tissue. By one day, the relative amounts...

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Bibliographic Details
Published in:Neurochemical research 1993-02, Vol.18 (2), p.209-218
Main Authors: ZHENG-YU XUE, GROSSFELD, R. M
Format: Article
Language:English
Subjects:
Animals
Astacoidea - metabolism
Biological and medical sciences
Central Nervous System - injuries
Central Nervous System - metabolism
Crustacea
Freshwater
Fundamental and applied biological sciences. Psychology
Heat-Shock Proteins - biosynthesis
Heat-Shock Proteins - metabolism
Invertebrates
Nerve Crush
Nerve Tissue Proteins - biosynthesis
Nerve Tissue Proteins - metabolism
Pathology
Procambarus
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Summary:By several days after a crush injury of crayfish CNS, the wound site heals. Changes in protein synthesis and accumulation occur at the lesion site and nearby. During the first few hours, synthesis of 35, 70, 90, and 150 kDa proteins is induced in the injured tissue. By one day, the relative amounts of 70-90 kDa proteins increase dramatically, particularly at the crush site and adjacent to it. The 70 kDa proteins, which are related to mammalian stress proteins (SPs), remain elevated for at least one month in the traumatized region or nearby. The crushed tissue contains an SP70 isoform not present in its uncrushed counterpart. These biochemical changes may reflect the cellular changes that accompany wound healing and/or a cellular stress response to compensate for the lesion. Since similar adaptations occur in the mammalian CNS, they may represent a phylogenetically conserved attempt to retard or repair CNS tissue deterioration.
ISSN:0364-3190
1573-6903
DOI:10.1007/BF01474686