Lipid peroxidation in experimental spinal cord injury: time-level relationship

Damage which occurs following spinal traumas is often irreversible. During recent years free oxygen radicals formed due to the pathological changes following neural tissue ischemia have been identified as being responsible for the ethio-pathogenesis of such damage. In our experimental study, model l...

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Bibliographic Details
Published in:Neurosurgical review 1993-01, Vol.16 (1), p.53-59
Main Authors: BARUT, S, CANBOLAT, A, BILGE, T, AYDIN, Y, COKNESELI, B, KAYA, U
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Female
Free Radicals
Injuries of the nervous system and the skull. Diseases due to physical agents
Lipid Peroxidation - physiology
Malondialdehyde - metabolism
Medical sciences
Rats
Rats, Wistar
Reactive Oxygen Species
Spinal Cord - physiopathology
Spinal Cord Injuries - physiopathology
Traumas. Diseases due to physical agents
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Summary:Damage which occurs following spinal traumas is often irreversible. During recent years free oxygen radicals formed due to the pathological changes following neural tissue ischemia have been identified as being responsible for the ethio-pathogenesis of such damage. In our experimental study, model lesions are formed in spinal cords of rats by standard trauma. Malondialdehyde (MDA), a lipid peroxidation product, was measured in the spinal tissues distal to the trauma in order to examine indirectly the time-quantity relationship of free oxygen radicals in the area. For this study 60 rats in six groups, including one control group, were used to determine the formation of MDA. Under a surgical microscope, the spines of all rats were exposed by C5-Th6 laminectomy, and pressure was applied to the spinal cords of animals, except the members of the control group, at the level of C7 by a Yaşargil aneurysm clip. MDA was measured in spinal cord tissues in order to determine free oxygen radicals at the first and fifteenth minutes and at the first, second, and fourth hours. The statistical evaluation of the findings revealed a significant increase in MDA, starting from the 15th minute after the compression, reaching a maximum at 1 hour, and then decreasing. This observation may provide an important guide for studies on prevention of neural destruction.
ISSN:0344-5607
1437-2320
DOI:10.1007/BF00308614