Activity-induced anorexia in rats does not affect hypothalamic neuropeptide gene expression chronically

Hypothalamic neuropeptides are thought to contribute to the pathophysiology of eating disorders. In an animal model with chronic abnormalities of energy expenditure, appetitive behavior, and body weight, without acute food restriction, we found alterations in peripheral levels of adrenocorticotropic...

Full description

Saved in:
Bibliographic Details
Published in:The International journal of eating disorders 1993-05, Vol.13 (4), p.399-405
Main Authors: Wong, M.L. (Yale University School of Medicine), Licinio, J, Gold, P.W, Glowa, J
Format: Article
Language:English
Subjects:
ACTIVIDAD FISICA
ACTIVITE PHYSIQUE
Adrenocorticotropic Hormone - blood
Adult and adolescent clinical studies
Animals
Anorexia Nervosa - genetics
APETITO
APPETIT
Appetitive Behavior
Biological and medical sciences
Body Weight - genetics
CEREBRO
Eating - genetics
Eating behavior disorders
ENCEPHALE
EXPRESION GENICA
EXPRESSION DES GENES
Gene Expression Regulation - physiology
Hydrocortisone - blood
Hypothalamic Hormones - genetics
Male
Medical sciences
Neuropeptides - genetics
PEPTIDE
PEPTIDOS
Physical Exertion
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
RAT
RATA
Rats
Rats, Sprague-Dawley
TRASTORNOS FUNCIONALES
TROUBLE FONCTIONNEL
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Hypothalamic neuropeptides are thought to contribute to the pathophysiology of eating disorders. In an animal model with chronic abnormalities of energy expenditure, appetitive behavior, and body weight, without acute food restriction, we found alterations in peripheral levels of adrenocorticotropic hormone and corticosterone, but no alterations in the expression of neuropeptides genes that are known to regulate ingestive behavior and food intake acutely. Our data suggest that activation of hypothalamic-pituitary-adrenal function in activity anorexia may not be due to increased transcription of corticotropin-releasing hormone gene, but might be related to posttranscriptional events or to other neuropeptides, such as arginine vasopressin. Furthermore, we suggest that abnormalities in neuropeptides observed in eating disorders may be caused by acute food restriction, rather than by chronic hyperactivity, anorexia, and low weight
ISSN:0276-3478
1098-108X
DOI:10.1002/1098-108X(199305)13:4<399::AID-EAT2260130408>3.0.CO;2-J