Association between apolipoprotein E genotype and outcome of traumatic brain injury

The prognosis of traumatic brain injury is quite variable and not fully explained by the known factors. This study is to examine if the polymorphism of apolipoprotein E (apoE) influences the outcome of traumatic brain injury. Over a period of twelve months, we prospectively studied 100 patients who...

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Published in:Acta neurochirurgica 2003-08, Vol.145 (8), p.649-654
Main Authors: Chiang, M-F, Chang, J-G, Hu, C-J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Apolipoproteins
Apolipoproteins E - genetics
Brain damage
Brain Injuries - genetics
Brain Injuries - therapy
Female
Genotype
Glasgow Coma Scale
Humans
Male
Middle Aged
People with disabilities
Polymorphism, Genetic - genetics
Predictive Value of Tests
Prognosis
Prospective Studies
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Chang, J-G
Hu, C-J
description The prognosis of traumatic brain injury is quite variable and not fully explained by the known factors. This study is to examine if the polymorphism of apolipoprotein E (apoE) influences the outcome of traumatic brain injury. Over a period of twelve months, we prospectively studied 100 patients who sustained traumatic brain injuries and were admitted to our neurosurgical unit. Nineteen patients were apoE4+ and 81 patients were apoE4-. There was no significant difference between apoE4+ and apoE4- groups in the cause of injury (p=0.288), type of brain injury (p=0.983) and choice of treatment (p=0.88). The proportion of patients with a lower GCS (
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This study is to examine if the polymorphism of apolipoprotein E (apoE) influences the outcome of traumatic brain injury. Over a period of twelve months, we prospectively studied 100 patients who sustained traumatic brain injuries and were admitted to our neurosurgical unit. Nineteen patients were apoE4+ and 81 patients were apoE4-. There was no significant difference between apoE4+ and apoE4- groups in the cause of injury (p=0.288), type of brain injury (p=0.983) and choice of treatment (p=0.88). The proportion of patients with a lower GCS (&lt;13), indicating a poor prognosis, was higher in the apoE4+ group (73.7%) than that in apoE4- group (61.7%), although the difference was not significant (p=0.654). Six patients (7.4%) in the apoE4- group and 5(26.3%) in the apoE4+ group had been drinking alcohol at the time of injury (p=0.018). The mean duration of hospital stay for apoE4+ patients was significantly longer than for apoE4- patients (p&lt;0.001). Six months after injury, 10 of 19 patients (52.6%) with apoE4 had an unfavorable outcome (dead, vegetative state, or severe disability) compared with 20 of the 81 (24.1%) patients without apoE4 (p=0.017). The apoE4+ patients had a significantly longer hospital stay and unfavorable outcomes after brain injury. This study discloses a significant genetic association between the apoE genotypes and outcomes of traumatic brain injury. 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This study is to examine if the polymorphism of apolipoprotein E (apoE) influences the outcome of traumatic brain injury. Over a period of twelve months, we prospectively studied 100 patients who sustained traumatic brain injuries and were admitted to our neurosurgical unit. Nineteen patients were apoE4+ and 81 patients were apoE4-. There was no significant difference between apoE4+ and apoE4- groups in the cause of injury (p=0.288), type of brain injury (p=0.983) and choice of treatment (p=0.88). The proportion of patients with a lower GCS (&lt;13), indicating a poor prognosis, was higher in the apoE4+ group (73.7%) than that in apoE4- group (61.7%), although the difference was not significant (p=0.654). Six patients (7.4%) in the apoE4- group and 5(26.3%) in the apoE4+ group had been drinking alcohol at the time of injury (p=0.018). The mean duration of hospital stay for apoE4+ patients was significantly longer than for apoE4- patients (p&lt;0.001). 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0942-0940
language eng
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source Springer Nature
subjects Adolescent
Adult
Aged
Aged, 80 and over
Apolipoproteins
Apolipoproteins E - genetics
Brain damage
Brain Injuries - genetics
Brain Injuries - therapy
Female
Genotype
Glasgow Coma Scale
Humans
Male
Middle Aged
People with disabilities
Polymorphism, Genetic - genetics
Predictive Value of Tests
Prognosis
Prospective Studies
title Association between apolipoprotein E genotype and outcome of traumatic brain injury
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