Photodynamic Therapy for the Treatment of Intranasal Tumors in 3 Dogs and 1 Cat

Three dogs and 1 cat with intranasal tumors were treated with pyropheophorbide-a-hexyl ether-based photodynamic therapy (PDT). PDT was well tolerated by all the animals, and no adverse effects from photosensitizer injection, such as cutaneous photosensiti-zation, were observed. Facial swelling was o...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2003-09, Vol.17 (5), p.727-729
Main Authors: Lucroy, Michael D, Long, Kevin R, Blaik, Maragaret A, Higbee, Russell G, Ridgway, Tisha D
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - drug therapy
Adenocarcinoma - veterinary
adverse effects
Animals
Canine
Cat Diseases - diagnostic imaging
Cat Diseases - drug therapy
Cats
Chlorophyll - administration & dosage
Chlorophyll - analogs & derivatives
Dog Diseases - diagnostic imaging
Dog Diseases - drug therapy
Dogs
Feline
Female
Hydroxyphenyl-phenylhydantoin
medicine
neoplasms
nose
Nose Neoplasms - drug therapy
Nose Neoplasms - veterinary
Photochemotherapy - veterinary
Pyropheophorbide-a-hexyl ether
radiotherapy
Tomography, X-Ray Computed - veterinary
veterinary medicine
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Summary:Three dogs and 1 cat with intranasal tumors were treated with pyropheophorbide-a-hexyl ether-based photodynamic therapy (PDT). PDT was well tolerated by all the animals, and no adverse effects from photosensitizer injection, such as cutaneous photosensiti-zation, were observed. Facial swelling was observed in all animals after each PDT treatment but resolved spontaneously within 72 hours after treatment. All animals had a decrease in severity of epistaxis, frequency of sneezing, and amount of nasal discharge after PDT. Clinical signs were controlled for variable time, although long-term responses were comparable with radiation therapy in 2 animals. This small case series demonstrates another application for PDT in veterinary medicine. On the basis of these findings, further studies are warranted to define the role of PDT in the management of intranasal tumors in dogs and cats.
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2003.tb02509.x