Predicting residual disease after excision of cervical dysplasia

Dysplastic epithelium at the resection margin after a cervical cone is known to predict persisting disease. We followed 702 women for 30 months after cervical excision to see which resection margin was predictive. The risk of persisting cytological abnormalities was doubled when CIN extended to the...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2003-10, Vol.110 (10), p.952-955
Main Authors: Johnson, Nicholas, Khalili, Mansoureh, Hirschowitz, Lynn, Ralli, Fran, Porter, Richard
Format: Article
Language:English
Subjects:
Adolescent
Adult
Analysis of Variance
Biological and medical sciences
Cervical Intraepithelial Neoplasia - pathology
Female
Female genital diseases
Follow-Up Studies
Gynecology. Andrology. Obstetrics
Humans
Medical sciences
Middle Aged
Neoplasm, Residual
Predictive Value of Tests
Prospective Studies
Risk Factors
Treatment Failure
Tumors
Uterine Cervical Dysplasia - pathology
Uterine Cervical Dysplasia - surgery
Uterine Cervical Neoplasms - pathology
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Summary:Dysplastic epithelium at the resection margin after a cervical cone is known to predict persisting disease. We followed 702 women for 30 months after cervical excision to see which resection margin was predictive. The risk of persisting cytological abnormalities was doubled when CIN extended to the endocervical resection margin and was doubled when there was evidence of HPV. In contrast, disease at the ectocervical resection margin and the grade of CIN were not associated with a higher risk of residual disease.
ISSN:1470-0328
1471-0528
DOI:10.1111/j.1471-0528.2003.99034.x