New insights into the possible role of bacteriophages in transplantation

Due to the increasing prevalence of drug-resistant bacterial infections in the “post-antibiotic era,” bacteriophages (bacterial viruses, BP) may be useful to administer to transplant recipients without exposing them to an increased risk of rejection, which occurs consequent to some viral infections....

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Bibliographic Details
Published in:Transplantation proceedings 2003-09, Vol.35 (6), p.2372-2373
Main Authors: Gorski, A, Nowaczyk, M, Weber-Dabrowska, B, Kniotek, M, Boratynski, J, Ahmed, A, Dabrowska, K, Wierzbicki, P, Switala-Jelen, K, Opolski, A
Format: Article
Language:English
Subjects:
Animals
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteriophages - immunology
Biological and medical sciences
Coliphages - immunology
Graft Rejection - prevention & control
Immunomodulators
Immunosuppression - methods
Medical sciences
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Pharmacology. Drug treatments
Skin Transplantation - immunology
Transplantation, Homologous - immunology
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Summary:Due to the increasing prevalence of drug-resistant bacterial infections in the “post-antibiotic era,” bacteriophages (bacterial viruses, BP) may be useful to administer to transplant recipients without exposing them to an increased risk of rejection, which occurs consequent to some viral infections. Herein we present evidence that at least some coliphages (T4) do not pose such risk. Interestingly, they may produce immunosuppressive effects extending transplant survival. Our data suggest that BP may be used in clinical transplantation to treat drug-resistant bacterial infections and perhaps as an adjunct to immunosuppressive therapy.
ISSN:0041-1345
1873-2623
DOI:10.1016/S0041-1345(03)00811-X