Calculation of volume flow rate by the proximal isovelocity surface area method: Simplified approach using color Doppler zero baseline shift

• Published in: Journal of the American College of Cardiology 1993-07, Vol.22 (1), p.277-282
• Main Authors: Utsunomiya, Toshinori, Doshi, Rajen, Patel, Dharmendra, Mehta, Kapil, Nguyen, Dat, Henry, Walter L., Gardin, Julius M.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Blood Flow Velocity; Blood Volume; Cardiovascular system; Echocardiography, Doppler - methods; Heart Valves - anatomy & histology; Heart Valves - physiopathology; Humans; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Models, Cardiovascular; Ultrasonic investigative techniques
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/0735-1097(93)90844-Q

Objectives. The goal of this study was to develop an accurate, simplified proximal isovelocity surface area (PISA) method for calculating volume flow rate using lower blue-red interface velocity produced by a color Doppler zero baseline shift technique. Background. The Doppler color proximal isovelocity surface area method has been shown to be accurate for calculating the volume flow rate (Q) across a narrowed orifice by the formula Q = PISA × Blue-red interface velocity. A hemispheric model is generally used to calculate proximal isovelocity surface area (PISA = 2πa2, where a = the radius corresponding to the blue-red interface velocity). Although a hemispheric model is simple, requiring measurement of one radius, it may underestimate the actual volume flow rate because, in the general case, the shape of a proximal isovelocity surface area is hemielliptic. Although a hemielliptic model is generally more accurate for calculating proximal isovelocity surface area, it is more complex, requiring measurement of two orthogonal radii. Methods. Sixteen in vitro constant flow model studies were performed using planar circular orifices (diameter range 6 to 16 mm). The blue-red interface velocity was changed from 3 to 54 cm/s using color Doppler zero baseline shift. Results. 1) With decreasing blue-red interface velocity, the size of the proximal isovelocity surface area was increased, and its shape changed from hemielliptic to hemispheric. 2) With the blue-red interface velocity in the range 11 to 15 cm/s, the proximal isovelocity surface area became nearly hemispheric; however, it was difficult to determine the blue-red interface radius at a blue-red interface velocity