Estimating medullary chemoreceptor blood flow from ventilatory-CO2 response transients: theory and data from anesthetized dogs

We examined the tracer wash-in technique for measuring blood flow for a specific experimental model in which medullary chemoreceptor blood flow is estimated using carbon dioxide as the tracer. Using a mathematical model, we calculated the flow values that would be estimated when blood flow is a func...

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Published in:Annals of biomedical engineering 1984, Vol.12 (1), p.1-13
Main Authors: ADAMS, J. M, GLASHEEN, W. P, SEVERNS, M. L
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carbon Dioxide - blood
Carbon Dioxide - metabolism
Chemoreceptor Cells - blood supply
Dogs
Female
Investigative techniques of hemodynamics
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Miscellaneous
Models, Biological
Regional Blood Flow
Respiration
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GLASHEEN, W. P
SEVERNS, M. L
description We examined the tracer wash-in technique for measuring blood flow for a specific experimental model in which medullary chemoreceptor blood flow is estimated using carbon dioxide as the tracer. Using a mathematical model, we calculated the flow values that would be estimated when blood flow is a function of the tracer concentration, CO2. The estimate was compared with three indices of time-varying blood flow: the steady-state blood flow before and after the step change of CO2 and the time-average blood flow. Estimated blood flow was found to be most closely related to the final value of flow. Perfusion estimates from five pentobarbital anesthetized dogs were 102 ml/100 g/min (S.D. 35) at an average of PaCO2 of 60.7 Torr.
doi_str_mv 10.1007/BF02410287
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1573-9686
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subjects Animals
Biological and medical sciences
Carbon Dioxide - blood
Carbon Dioxide - metabolism
Chemoreceptor Cells - blood supply
Dogs
Female
Investigative techniques of hemodynamics
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Miscellaneous
Models, Biological
Regional Blood Flow
Respiration
title Estimating medullary chemoreceptor blood flow from ventilatory-CO2 response transients: theory and data from anesthetized dogs
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