Gastrointestinal absorption of metals ( 51Cr, 65Zn, 95mTc, 109Cd, 113Sn, 147Pm, and 238Pu) by rats and swine

Adult and neonatal rats and neonatal pigs were gavaged with solutions of metal radionuclides to determine gastrointestinal absorption. Zinc-65 and technetium-95m were well-absorbed by both age groups; chromium-51, cadmium-109, tin-113, promethium-147, and plutonium-238 were not. The quantities of th...

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Bibliographic Details
Published in:Environmental research 1984-12, Vol.35 (2), p.439-453
Main Authors: Sullivan, M.F., Miller, B.M., Goebel, J.C.
Format: Article
Language:English
Subjects:
ABSORCION
ABSORPTION
Age Factors
Animals
Animals, Newborn
APPAREIL DIGESTIF
Autoradiography
Biological and medical sciences
Biological effects of radiation
CADMIO
CADMIUM
Cadmium - metabolism
CERDO
CHROME
CHROMIUM
Chromium Radioisotopes - metabolism
CINC
CROMO
DIGESTIVE SYSTEM
Duodenum - metabolism
ESTANO
ETAIN
Female
Fundamental and applied biological sciences. Psychology
Humans
Ileum - metabolism
Intestinal Absorption
ISOTOPE RADIOACTIF
PLUTONIO
PLUTONIUM
Plutonium - metabolism
PORCIN
promethium
Promethium - metabolism
Radiocontamination
RADIOISOTOPES
Radioisotopes - metabolism
RADIOISOTOPOS
RAT
RATA
RATS
Rats, Inbred Strains
SISTEMA DIGESTIVO
Species Specificity
SWINE
TECHNETIUM
Technetium - metabolism
TIN
Tin - metabolism
Tissue Distribution
Tissues, organs and organisms biophysics
ZINC
Zinc Radioisotopes - metabolism
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Summary:Adult and neonatal rats and neonatal pigs were gavaged with solutions of metal radionuclides to determine gastrointestinal absorption. Zinc-65 and technetium-95m were well-absorbed by both age groups; chromium-51, cadmium-109, tin-113, promethium-147, and plutonium-238 were not. The quantities of the poorly absorbed metals that were absorbed by neonates were between 4 and 100 times higher than those absorbed by adult rats. Autoradiograms prepared from the entire small intestine of the neonatal rat showed that 109Cd was retained in the duodenum. In contrast, measurements in the piglets showed much higher 109Cd retention in the ileum than in the duodenum. Autoradiograms and radiochemical measurements of 147Pm and 238Pu in both neonatal rats and swine showed the highest level of retention in the ileum. The results indicate that, for most of the metals studied, absorption from the gastrointestinal tract is substantially higher for neonatal than for adult rats.
ISSN:0013-9351
1096-0953
DOI:10.1016/0013-9351(84)90151-8