Transcriptional antitermination

Antiterminator proteins control gene expression by recognizing control signals near the promoter and preventing transcriptional termination which would otherwise occur at sites that may be a long way downstream. The N protein of bacteriophage λ recognizes a sequence in the nascent RNA, and modifies...

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Bibliographic Details
Published in:Nature (London) 1993-07, Vol.364 (6436), p.401-406
Main Authors: Greenblatt, Jack, Nodwell, Justin R, Mason, Stephen W
Format: Article
Language:English
Subjects:
AIDS/HIV
Bacteria
Bacteriophage lambda - genetics
Base Sequence
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Gene Products, tat - physiology
Genetics
HIV
HIV-1 - genetics
Human immunodeficiency virus
human immunodeficiency virus 1
Humanities and Social Sciences
Molecular and cellular biology
Molecular genetics
Molecular Sequence Data
multidisciplinary
phage lambda
review-article
Science
Science (multidisciplinary)
tat Gene Products, Human Immunodeficiency Virus
Transcription, Genetic - physiology
Transcription. Transcription factor. Splicing. Rna processing
Viral Proteins - physiology
Viral Regulatory and Accessory Proteins - physiology
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Summary:Antiterminator proteins control gene expression by recognizing control signals near the promoter and preventing transcriptional termination which would otherwise occur at sites that may be a long way downstream. The N protein of bacteriophage λ recognizes a sequence in the nascent RNA, and modifies RNA polymerase by catalysing the formation of a stable ribonucleo-protein complex on its surface, whereas the λ Q protein recognizes a sequence in the DNA. These mechanisms of antitermination in λ provide models for analysing antitermination in viruses such as HIV-1 and in eukaryotic genes.
ISSN:0028-0836
1476-4687
DOI:10.1038/364401a0