Comparison of atropine and glycopyrronium in patients with pre‐existing cardiac disease

Summary The effects of atropine and glycopyrronium, when given intravenously with neostigmine during the reversal of neuromuscular blockade in patients with cardiovascular disease, were compared in a double blind trial. Atropine was associated with a significantly greater elevation of heart rate and...

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Bibliographic Details
Published in:Anaesthesia 1984-12, Vol.39 (12), p.1207-1213
Main Authors: MOSTAFA, S. M., VUCEVIC, M.
Format: Article
Language:English
Subjects:
Aged
Anesthesia
Anesthesia depending on patient's condition
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Atropine - pharmacology
atropine, glycopyrronium
Biological and medical sciences
Blood Pressure - drug effects
Coronary Disease - complications
Double-Blind Method
Electrocardiography
Female
Glycopyrrolate - pharmacology
Heart
Heart Diseases - complications
Heart Rate - drug effects
Humans
Intubation, Intratracheal
Male
Medical sciences
Myocardial Infarction - complications
Parasympathetic nervous system
pulse rate
Pyrrolidines - pharmacology
Random Allocation
Surgical Procedures, Operative
Time Factors
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Summary:Summary The effects of atropine and glycopyrronium, when given intravenously with neostigmine during the reversal of neuromuscular blockade in patients with cardiovascular disease, were compared in a double blind trial. Atropine was associated with a significantly greater elevation of heart rate and rate‐pressure product than glycopyrronium. This elevation was also more sustained with atropine. The entire atropine population also showed a significantly greater incidence of ST‐segment depression on the electrocardiogram than that observed in those who had received glycopyrronium. Furthermore, patients with ischaemic heart disease and previous myocardial infarction who received atropine showed a significantly greater incidence of dysrhythmias than those given glycopyrronium. It is suggested that at the time of reversal of neuromuscular blockade in patients with cardiovascular disease, glycopyrronium is a more suitable agent than atropine.
ISSN:0003-2409
1365-2044
DOI:10.1111/j.1365-2044.1984.tb06433.x