Contact allergy to fragrances: current patch test results (2005-2008) from the Information Network of Departments of Dermatology

Background: Contact sensitization to fragrances is common both in clinical and in population samples. The spectrum of allergens is broad and diverse, and to some extent covered by a set of screening agents. Objectives: To examine the current frequency of contact sensitization to fragrance allergens...

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Bibliographic Details
Published in:Contact dermatitis 2010-11, Vol.63 (5), p.254-261
Main Authors: Uter, Wolfgang, Geier, Johannes, Frosch, Peter, Schnuch, Axel
Format: Article
Language:English
Subjects:
Adult
Allergens - adverse effects
Allergic diseases
Allergies
Biological and medical sciences
clinical epidemiology
contact allergy
Cosmetics - adverse effects
Departments
Dermatitis, Allergic Contact - diagnosis
Dermatitis, Allergic Contact - epidemiology
Dermatology
Domestic and cosmetic products toxicology
Female
fragrances
Germany - epidemiology
Humans
Immunopathology
Male
Medical sciences
Patch Tests - methods
Patch Tests - statistics & numerical data
Prevalence
Skin allergic diseases. Stinging insect allergies
Toxicology
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Summary:Background: Contact sensitization to fragrances is common both in clinical and in population samples. The spectrum of allergens is broad and diverse, and to some extent covered by a set of screening agents. Objectives: To examine the current frequency of contact sensitization to fragrance allergens in patients routinely patch tested for suspected allergic contact dermatitis with the baseline series and special series. Patients and methods: Between 2005 and 2008, 40 709 patients were patch tested in the departments of the Information Network of Departments of Dermatology (http://www.ivdk.org). Results with selected fragrances were analysed. Results: Of all patients tested with the German baseline series, 15.1% reacted positively to fragrance mix (FM) I (6.6% positive), FM II (4.6% positive) or Myroxylon pereirae resin (balsam of Peru, 6.8% positive). Among the single constituents of FM I, Evernia prunastri [oak moss absolute (abs.)] was the leading allergen, and amyl cinnamal the least frequent allergen. Among fragrances not included in FM I or FM II, Evernia furfuracea (tree moss abs.) was the most common allergen. Conclusions: For diagnostic purposes, it is necessary to combine several screening agents. The frequency of contact sensitization differs greatly between single fragrances.
ISSN:0105-1873
1600-0536
DOI:10.1111/j.1600-0536.2010.01759.x