Anorectal dysfunction and delayed colonic transit in patients with progressive systemic sclerosis

We studied 14 unselected patients with progressive systemic sclerosis (PSS), six with constipation, and eight with normal bowel habits. A control group, matched for age and sex, comprised six patients with idiopathic constipation and seven healthy subjects. Anorectal manometry was performed with per...

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Bibliographic Details
Published in:Digestive diseases and sciences 1993-08, Vol.38 (8), p.1525-1529
Main Authors: BASILISCO, G, BARBERA, R, VANOLI, M, BIANCHI, P
Format: Article
Language:English
Subjects:
Adult
Anal Canal - physiopathology
Biological and medical sciences
Colon - physiopathology
Constipation - etiology
Constipation - physiopathology
Female
Gastrointestinal Transit - physiology
Humans
Male
Manometry
Medical sciences
Middle Aged
Reference Values
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Scleroderma, Systemic - complications
Scleroderma, Systemic - physiopathology
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Summary:We studied 14 unselected patients with progressive systemic sclerosis (PSS), six with constipation, and eight with normal bowel habits. A control group, matched for age and sex, comprised six patients with idiopathic constipation and seven healthy subjects. Anorectal manometry was performed with perfused catheters and segmental colonic transit was measured by a radiopaque marker technique. The resting pressure of the anal canal was significantly reduced in PSS with constipation (P < 0.05). The rectoanal inhibitory reflex was detected in only one PSS patient with constipation, but was present in seven of eight PSS patients with normal bowel habits and in all controls (P < 0.01). Total and right colonic transit times were significantly delayed in PSS with constipation and in patients with idiopathic constipation (P < 0.05). In patients with PSS, colonic transit was delayed and anal sphincter function was impaired in constipated patients, suggesting involvement of both the colon and the anorectum by the disease.
ISSN:0163-2116
1573-2568
DOI:10.1007/bf01308615