Reduction of oxidized guanosine by dietary carotenoids: A pulse radiolysis study

► Oxidative damage of nucleosides involves guanosine. ► Radical quenching reduces oxidation of guanosine. ► Dietary carotenoids also convert oxidised guanosine to guanosine. ► Carotenoids give additional protection against free radical-induced damage of nucleic acid bases. ► Benefits for dietary car...

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Bibliographic Details
Published in:Archives of biochemistry and biophysics 2010-12, Vol.504 (1), p.100-103
Main Authors: Edge, Ruth, Gaikwad, Parimal, Navaratnam, Suppiah, Madhava Rao, B.S., George Truscott, T.
Format: Article
Language:English
Subjects:
Astaxanthin
Carotenoids - metabolism
Diet
Electron transfer
Electron Transport
Guanosine
Guanosine - metabolism
Kinetics
Lycopene
Nucleosides - metabolism
Pulse Radiolysis - methods
Radicals
Zeaxanthin
β-Carotene
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Summary:► Oxidative damage of nucleosides involves guanosine. ► Radical quenching reduces oxidation of guanosine. ► Dietary carotenoids also convert oxidised guanosine to guanosine. ► Carotenoids give additional protection against free radical-induced damage of nucleic acid bases. ► Benefits for dietary carotenoids against oxidation damage. Time-resolved pulse radiolysis investigations reported herein show that the carotenoids β-carotene, lycopene, zeaxanthin and astaxanthin (the last two are xanthophylls – oxygen containing carotenoids) are capable of both reducing oxidized guanosine as well as minimizing its formation. The reaction of the carotenoid with the oxidized guanosine produces the radical cation of the carotenoid. This behavior contrasts with the reactions between the amino acids and dietary carotenoids where the carotenoid radical cations oxidized the amino acids (tryptophan, cysteine and tyrosine) at physiological pH.
ISSN:0003-9861
1096-0384
DOI:10.1016/j.abb.2010.07.026