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Marked Species-Difference in the Vascular Angiotensin II-Forming Pathways: Humans versus Rodents

Using isolated arteries, we demonstrated a marked difference in the angiotensin II-forming systems between human and rodent vessels. In human arteries, only 30-40% of the conversion of angiotensin I to angiotensin II depended on the angiotensin-converting enzyme (ACE), and the rest of the angiotensi...

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Bibliographic Details
Published in:Japanese journal of pharmacology 1993, Vol.62(2), pp.207-210
Main Authors: Okunishi, Hideki, Oka, Yuko, Shiota, Naotaka, Kawamoto, Tatsuhiko, Song, Keifu, Miyazaki, Mizuo
Format: Article
Language:English
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Summary:Using isolated arteries, we demonstrated a marked difference in the angiotensin II-forming systems between human and rodent vessels. In human arteries, only 30-40% of the conversion of angiotensin I to angiotensin II depended on the angiotensin-converting enzyme (ACE), and the rest of the angiotensin II formation was ascribed to chymostatin-sensitive angiotensin II-generating enzyme (CAGE). On the contrary, angiotensin II formation in rodent arteries totally depended upon ACE, without any sign of CAGE involvement. Such a marked species-difference can be relevant to the reported difference between humans and rodents in the ACE inhibitor effects on the myointimal hyperplasia after intimal balloon injury.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.62.207