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Biosynthesis of vitamin B12 : discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group
In the vitamin B12 biosynthetic pathway the enzymes responsible for the conversion of precorrin-3 to precorrin-4 have been identified as the gene products of cobG and cobJ from Pseudomonas denitrificans. CobG catalyzes the oxidation of precorrin-3 to precorrin-3x (a hydroxy lactone) whereas CobJ is...
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| Published in: | FEBS letters 1993-09, Vol.331 (1-2), p.105-108 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 108 |
| container_issue | 1-2 |
| container_start_page | 105 |
| container_title | FEBS letters |
| container_volume | 331 |
| creator | SCOTT, A. I ROESSNER, C. A STOLOWICH, N. J SPENCER, J. B MIN, C OZAKI, S.-I |
| description | In the vitamin B12 biosynthetic pathway the enzymes responsible for the conversion of precorrin-3 to precorrin-4 have been identified as the gene products of cobG and cobJ from Pseudomonas denitrificans. CobG catalyzes the oxidation of precorrin-3 to precorrin-3x (a hydroxy lactone) whereas CobJ is a SAM-dependent C-17 methyl transferase and is necessary for ring contraction. A mechanism for ring contraction is proposed. |
| doi_str_mv | 10.1016/0014-5793(93)80306-F |
| format | article |
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I ; ROESSNER, C. A ; STOLOWICH, N. J ; SPENCER, J. B ; MIN, C ; OZAKI, S.-I</creator><creatorcontrib>SCOTT, A. I ; ROESSNER, C. A ; STOLOWICH, N. J ; SPENCER, J. B ; MIN, C ; OZAKI, S.-I</creatorcontrib><description>In the vitamin B12 biosynthetic pathway the enzymes responsible for the conversion of precorrin-3 to precorrin-4 have been identified as the gene products of cobG and cobJ from Pseudomonas denitrificans. CobG catalyzes the oxidation of precorrin-3 to precorrin-3x (a hydroxy lactone) whereas CobJ is a SAM-dependent C-17 methyl transferase and is necessary for ring contraction. A mechanism for ring contraction is proposed.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(93)80306-F</identifier><identifier>PMID: 8405386</identifier><identifier>CODEN: FEBLAL</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>Bacterial Proteins ; Bacteriology ; Base Sequence ; Biological and medical sciences ; DNA, Single-Stranded ; Fundamental and applied biological sciences. Psychology ; Metabolism. Enzymes ; Methylation ; Methyltransferases - genetics ; Methyltransferases - metabolism ; Microbiology ; Molecular Sequence Data ; Oxidation-Reduction ; Oxygenases - genetics ; Oxygenases - metabolism ; Pseudomonas - enzymology ; S-Adenosylmethionine - metabolism ; Uroporphyrins - biosynthesis ; Vitamin B 12 - biosynthesis</subject><ispartof>FEBS letters, 1993-09, Vol.331 (1-2), p.105-108</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3767194$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8405386$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SCOTT, A. I</creatorcontrib><creatorcontrib>ROESSNER, C. A</creatorcontrib><creatorcontrib>STOLOWICH, N. J</creatorcontrib><creatorcontrib>SPENCER, J. B</creatorcontrib><creatorcontrib>MIN, C</creatorcontrib><creatorcontrib>OZAKI, S.-I</creatorcontrib><title>Biosynthesis of vitamin B12 : discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>In the vitamin B12 biosynthetic pathway the enzymes responsible for the conversion of precorrin-3 to precorrin-4 have been identified as the gene products of cobG and cobJ from Pseudomonas denitrificans. CobG catalyzes the oxidation of precorrin-3 to precorrin-3x (a hydroxy lactone) whereas CobJ is a SAM-dependent C-17 methyl transferase and is necessary for ring contraction. A mechanism for ring contraction is proposed.</description><subject>Bacterial Proteins</subject><subject>Bacteriology</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>DNA, Single-Stranded</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Metabolism. Enzymes</subject><subject>Methylation</subject><subject>Methyltransferases - genetics</subject><subject>Methyltransferases - metabolism</subject><subject>Microbiology</subject><subject>Molecular Sequence Data</subject><subject>Oxidation-Reduction</subject><subject>Oxygenases - genetics</subject><subject>Oxygenases - metabolism</subject><subject>Pseudomonas - enzymology</subject><subject>S-Adenosylmethionine - metabolism</subject><subject>Uroporphyrins - biosynthesis</subject><subject>Vitamin B 12 - biosynthesis</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNo9kE1LxDAQhoMouq7-A4UcRPRQnTTNR72p-AWCFz0vaZu4kTZZk3SxHvztVi2ehpfnmYF5ETogcEaA8HMAUmRMlPSkpKcSKPDsdgPNiBQ0owWXm2j2r-yg3RjfYMySlNtoWxbAqOQz9HVlfRxcWupoI_YGr21SnXX4iuT4Ajc21n6tw_CDRglr9zl0OmLjA_YftlHJrjUO1r3i2rsUVJ2sd1i5BlsXdfhN067xfUhL3Om0HFr8Gny_2kNbRrVR709zjl5ub56v77PHp7uH68vHbEUYpMyUnFXQMFoZ4LkApVlOK6IaUhpJiZaC8DxXwnAlRMGFhKKugEFpCMulYnSOjv_uroJ_73VMi278TLetctr3cSE4QEFZMYqHk9hXnW4Wq2A7FYbFVNjIjyauYq1aE5SrbfzXqOCClAX9Bjfte0s</recordid><startdate>19930927</startdate><enddate>19930927</enddate><creator>SCOTT, A. 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Enzymes</topic><topic>Methylation</topic><topic>Methyltransferases - genetics</topic><topic>Methyltransferases - metabolism</topic><topic>Microbiology</topic><topic>Molecular Sequence Data</topic><topic>Oxidation-Reduction</topic><topic>Oxygenases - genetics</topic><topic>Oxygenases - metabolism</topic><topic>Pseudomonas - enzymology</topic><topic>S-Adenosylmethionine - metabolism</topic><topic>Uroporphyrins - biosynthesis</topic><topic>Vitamin B 12 - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCOTT, A. I</creatorcontrib><creatorcontrib>ROESSNER, C. A</creatorcontrib><creatorcontrib>STOLOWICH, N. J</creatorcontrib><creatorcontrib>SPENCER, J. 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B</au><au>MIN, C</au><au>OZAKI, S.-I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biosynthesis of vitamin B12 : discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1993-09-27</date><risdate>1993</risdate><volume>331</volume><issue>1-2</issue><spage>105</spage><epage>108</epage><pages>105-108</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><coden>FEBLAL</coden><abstract>In the vitamin B12 biosynthetic pathway the enzymes responsible for the conversion of precorrin-3 to precorrin-4 have been identified as the gene products of cobG and cobJ from Pseudomonas denitrificans. CobG catalyzes the oxidation of precorrin-3 to precorrin-3x (a hydroxy lactone) whereas CobJ is a SAM-dependent C-17 methyl transferase and is necessary for ring contraction. A mechanism for ring contraction is proposed.</abstract><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>8405386</pmid><doi>10.1016/0014-5793(93)80306-F</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1993-09, Vol.331 (1-2), p.105-108 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76004354 |
| source | ScienceDirect Additional Titles |
| subjects | Bacterial Proteins Bacteriology Base Sequence Biological and medical sciences DNA, Single-Stranded Fundamental and applied biological sciences. Psychology Metabolism. Enzymes Methylation Methyltransferases - genetics Methyltransferases - metabolism Microbiology Molecular Sequence Data Oxidation-Reduction Oxygenases - genetics Oxygenases - metabolism Pseudomonas - enzymology S-Adenosylmethionine - metabolism Uroporphyrins - biosynthesis Vitamin B 12 - biosynthesis |
| title | Biosynthesis of vitamin B12 : discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group |
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