Preclinical and Clinical Studies on Application of Human Myoblasts in Regeneration of the Postinfarction Heart

Abstract Principal definitions of stem cell subdivisions as well as of the physiology of the renewal of their descendants have been elucidated in recent years. Regeneration mechanisms have been outlined using as an example the intestinal villus niche. Sources of stem cells for preclinical studies an...

Full description

Saved in:
Bibliographic Details
Published in:Transplantation proceedings 2010-10, Vol.42 (8), p.3323-3327
Main Author: Kurpisz, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Transplantation
Clinical Trials as Topic
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Heart - physiopathology
Humans
Medical sciences
Myoblasts - cytology
Myocardial Infarction - pathology
Myocardial Infarction - therapy
Regeneration
Surgery
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Tissue, organ and graft immunology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Principal definitions of stem cell subdivisions as well as of the physiology of the renewal of their descendants have been elucidated in recent years. Regeneration mechanisms have been outlined using as an example the intestinal villus niche. Sources of stem cells for preclinical studies and the main conclusions from clinical trials have been developed in the vast majority in the 21st century. Meta-analyses and summaries have been focused so far on bone marrow stem cells and muscle-derived stem cells, which have been most often tried to date. Polish clinical trials on postinfarcted hearts have been consistent with the world literature regarding the major conclusions for myocardial regeneration. The controversies include possible side effects of stem cell applications. The necessity for genetic modification of the stem cells, which are mainly myoblasts, has been justified by the results of recently performed trials, initial examples including transfections of proangiogenic factors into human primary myoblast suspensions.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2010.07.025