An antiemetic is antidotal to the satiety effects of cholecystokinin

Although cholecystokinin (CCK) has been proposed as a satiety agent 1–4 , this property has been disputed by some who claim that the compound exerts its ‘satiety’ effects by inducing aversion 5–7 . We considered that if CCK-induced reductions in food intake occur through the mechanism of normal sati...

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Bibliographic Details
Published in:Nature (London) 1985-05, Vol.315 (6017), p.321-322
Main Authors: Moore, Beth O, Deutsch, J. A
Format: Article
Language:English
Subjects:
Animals
antiemetics
Antiemetics - pharmacology
Benzamides - pharmacology
Biological and medical sciences
cholecystokinin
Cholecystokinin - antagonists & inhibitors
Digestive system
Humanities and Social Sciences
letter
Male
Medical sciences
multidisciplinary
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
Satiation - drug effects
satiety
Science
Science (multidisciplinary)
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Summary:Although cholecystokinin (CCK) has been proposed as a satiety agent 1–4 , this property has been disputed by some who claim that the compound exerts its ‘satiety’ effects by inducing aversion 5–7 . We considered that if CCK-induced reductions in food intake occur through the mechanism of normal satiety, CCK-induced satiety and normal satiety should respond in the same way to a pharmacological challenge. We demonstrate here that the administration of an antiemetic to rats significantly attenuates the food intake reduction caused by exogenously administered CCK but does not increase normal consumption. The effects of endogenous CCK are therefore quite different from those of exogenous CCK, making any previous study equating exogenous CCK effects with natural satiety problematic.
ISSN:0028-0836
1476-4687
DOI:10.1038/315321a0