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An antiemetic is antidotal to the satiety effects of cholecystokinin
Although cholecystokinin (CCK) has been proposed as a satiety agent 1–4 , this property has been disputed by some who claim that the compound exerts its ‘satiety’ effects by inducing aversion 5–7 . We considered that if CCK-induced reductions in food intake occur through the mechanism of normal sati...
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| Published in: | Nature (London) 1985-05, Vol.315 (6017), p.321-322 |
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| Main Authors: | , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c395t-195247d2eea73493db1d1df52881dac588a9ab5fc90a264fe091656d8b82bc5b3 |
| container_end_page | 322 |
| container_issue | 6017 |
| container_start_page | 321 |
| container_title | Nature (London) |
| container_volume | 315 |
| creator | Moore, Beth O Deutsch, J. A |
| description | Although cholecystokinin (CCK) has been proposed as a satiety agent
1–4
, this property has been disputed by some who claim that the compound exerts its ‘satiety’ effects by inducing aversion
5–7
. We considered that if CCK-induced reductions in food intake occur through the mechanism of normal satiety, CCK-induced satiety and normal satiety should respond in the same way to a pharmacological challenge. We demonstrate here that the administration of an antiemetic to rats significantly attenuates the food intake reduction caused by exogenously administered CCK but does not increase normal consumption. The effects of endogenous CCK are therefore quite different from those of exogenous CCK, making any previous study equating exogenous CCK effects with natural satiety problematic. |
| doi_str_mv | 10.1038/315321a0 |
| format | article |
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1–4
, this property has been disputed by some who claim that the compound exerts its ‘satiety’ effects by inducing aversion
5–7
. We considered that if CCK-induced reductions in food intake occur through the mechanism of normal satiety, CCK-induced satiety and normal satiety should respond in the same way to a pharmacological challenge. We demonstrate here that the administration of an antiemetic to rats significantly attenuates the food intake reduction caused by exogenously administered CCK but does not increase normal consumption. The effects of endogenous CCK are therefore quite different from those of exogenous CCK, making any previous study equating exogenous CCK effects with natural satiety problematic.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/315321a0</identifier><identifier>PMID: 4000263</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; antiemetics ; Antiemetics - pharmacology ; Benzamides - pharmacology ; Biological and medical sciences ; cholecystokinin ; Cholecystokinin - antagonists & inhibitors ; Digestive system ; Humanities and Social Sciences ; letter ; Male ; Medical sciences ; multidisciplinary ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Satiation - drug effects ; satiety ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1985-05, Vol.315 (6017), p.321-322</ispartof><rights>Springer Nature Limited 1985</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-195247d2eea73493db1d1df52881dac588a9ab5fc90a264fe091656d8b82bc5b3</citedby><cites>FETCH-LOGICAL-c395t-195247d2eea73493db1d1df52881dac588a9ab5fc90a264fe091656d8b82bc5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9270012$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4000263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moore, Beth O</creatorcontrib><creatorcontrib>Deutsch, J. A</creatorcontrib><title>An antiemetic is antidotal to the satiety effects of cholecystokinin</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Although cholecystokinin (CCK) has been proposed as a satiety agent
1–4
, this property has been disputed by some who claim that the compound exerts its ‘satiety’ effects by inducing aversion
5–7
. We considered that if CCK-induced reductions in food intake occur through the mechanism of normal satiety, CCK-induced satiety and normal satiety should respond in the same way to a pharmacological challenge. We demonstrate here that the administration of an antiemetic to rats significantly attenuates the food intake reduction caused by exogenously administered CCK but does not increase normal consumption. The effects of endogenous CCK are therefore quite different from those of exogenous CCK, making any previous study equating exogenous CCK effects with natural satiety problematic.</description><subject>Animals</subject><subject>antiemetics</subject><subject>Antiemetics - pharmacology</subject><subject>Benzamides - pharmacology</subject><subject>Biological and medical sciences</subject><subject>cholecystokinin</subject><subject>Cholecystokinin - antagonists & inhibitors</subject><subject>Digestive system</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Male</subject><subject>Medical sciences</subject><subject>multidisciplinary</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Satiation - drug effects</subject><subject>satiety</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><recordid>eNqFkMtOwzAQRS0EKuUh8QOgLBCCRcDPxF6i8pQqsYF15DhjmpLaYDuL_j0pLV0hsfJY5-jO6CJ0QvA1wUzeMCIYJRrvoDHhZZHzQpa7aIwxlTmWrNhHBzHOMcaClHyERnwYacHG6O7WZdqlFhaQWpO18efX-KS7LPkszSCLesBpmYG1YFLMvM3MzHdgljH5j9a17gjtWd1FON68h-jt4f518pRPXx6fJ7fT3DAlUk6UoLxsKIAuGVesqUlDGiuolKTRRkipla6FNQprWnALWJFCFI2sJa2NqNkhuljnfgb_1UNM1aKNBrpOO_B9rMqCMMUZ_VcknEisMB_Ey7Vogo8xgK0-Q7vQYVkRXK2arX6bHdTTTWZfL6DZipsqB36-4Toa3dmgnWnjVlO0xJisTrtaa3Eg7h1CNfd9cENtf608W7tOpz7ANmsrfANDGZX5</recordid><startdate>19850523</startdate><enddate>19850523</enddate><creator>Moore, Beth O</creator><creator>Deutsch, J. A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7SQ</scope><scope>7X8</scope></search><sort><creationdate>19850523</creationdate><title>An antiemetic is antidotal to the satiety effects of cholecystokinin</title><author>Moore, Beth O ; Deutsch, J. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-195247d2eea73493db1d1df52881dac588a9ab5fc90a264fe091656d8b82bc5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>antiemetics</topic><topic>Antiemetics - pharmacology</topic><topic>Benzamides - pharmacology</topic><topic>Biological and medical sciences</topic><topic>cholecystokinin</topic><topic>Cholecystokinin - antagonists & inhibitors</topic><topic>Digestive system</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>Male</topic><topic>Medical sciences</topic><topic>multidisciplinary</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Satiation - drug effects</topic><topic>satiety</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moore, Beth O</creatorcontrib><creatorcontrib>Deutsch, J. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Endocrinology Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moore, Beth O</au><au>Deutsch, J. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An antiemetic is antidotal to the satiety effects of cholecystokinin</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1985-05-23</date><risdate>1985</risdate><volume>315</volume><issue>6017</issue><spage>321</spage><epage>322</epage><pages>321-322</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>Although cholecystokinin (CCK) has been proposed as a satiety agent
1–4
, this property has been disputed by some who claim that the compound exerts its ‘satiety’ effects by inducing aversion
5–7
. We considered that if CCK-induced reductions in food intake occur through the mechanism of normal satiety, CCK-induced satiety and normal satiety should respond in the same way to a pharmacological challenge. We demonstrate here that the administration of an antiemetic to rats significantly attenuates the food intake reduction caused by exogenously administered CCK but does not increase normal consumption. The effects of endogenous CCK are therefore quite different from those of exogenous CCK, making any previous study equating exogenous CCK effects with natural satiety problematic.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>4000263</pmid><doi>10.1038/315321a0</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1985-05, Vol.315 (6017), p.321-322 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76139432 |
| source | Nature |
| subjects | Animals antiemetics Antiemetics - pharmacology Benzamides - pharmacology Biological and medical sciences cholecystokinin Cholecystokinin - antagonists & inhibitors Digestive system Humanities and Social Sciences letter Male Medical sciences multidisciplinary Pharmacology. Drug treatments Rats Rats, Inbred Strains Satiation - drug effects satiety Science Science (multidisciplinary) |
| title | An antiemetic is antidotal to the satiety effects of cholecystokinin |
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