Circulatory changes in newborn lambs with experimental polycythemia: comparison between fetal and adult type blood

Hemodynamic effects of increased hematocrit were compared in two groups of newborn lambs. In the first group (fetal type blood), exchange transfusions were carried out using packed red blood cells obtained from newborn lambs within one to two hours after birth. In the second group (adult type blood)...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1985-06, Vol.75 (6), p.1054-1060
Main Authors: FOURON, J.-C, BARD, H, RIOPEL, L, DE MUYLDER, X, VAN AMERINGEN, M.-R, URFER, F
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Applied sciences
Biological and medical sciences
Blood Pressure
Blood Viscosity
Cardiac Output
Diseases of red blood cells
Exact sciences and technology
Fetal Blood - physiology
Hematocrit
Hematologic and hematopoietic diseases
Medical sciences
Other techniques and industries
Polycythemia - blood
Polycythemia - physiopathology
Polycythemias
Sheep - blood
Vascular Resistance
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Summary:Hemodynamic effects of increased hematocrit were compared in two groups of newborn lambs. In the first group (fetal type blood), exchange transfusions were carried out using packed red blood cells obtained from newborn lambs within one to two hours after birth. In the second group (adult type blood), the same procedure was carried out using adult sheep blood. In both groups, hematocrit values ranging between 70% and 80% were reached. The increase in hematocrit caused a decrease in cardiac output due to an increase in peripheral resistance. Pulmonary resistance increased more than systemic resistance. However, the increase in pulmonary resistance was significantly greater in the polycythemic newborn lambs with adult blood. A right-to-left shunt through a patent ductus or a foramen ovale was noted in six of the eight lambs included in this group. On the other hand, none of the seven polycythemic newborn lambs with fetal blood developed signs of right-to-left shunting. It is concluded that during neonatal polycythemia, the level of hematocrit is not the sole factor responsible for the hemodynamic changes observed. Other unknown influences related either to the red cells or the plasma must impinge upon the pulmonary circulation to alter vascular resistance.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.75.6.1054