Hippocampal Cell Firing Correlates of Delayed-Match-to-Sample Performance in the Rat

Hippocampal CA1 and CA3 neurons were recorded in rats performing a delayed-match-to-sample (DMTS) task. Complex spike cells showed significant firing peaks following sample and match responses and during delivery of water reward. Individual cells were classified into 4 subtypes according to the pres...

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Bibliographic Details
Published in:Behavioral neuroscience 1993-10, Vol.107 (5), p.715-739
Main Authors: Hampson, Robert E, Heyser, Charles J, Deadwyler, Sam A
Format: Article
Language:English
Subjects:
Animal
Animal behavior
Animals
Appetitive Behavior - physiology
Attention - physiology
Behavioral psychophysiology
Biological and medical sciences
Discrimination Learning - physiology
Electrical Activity
Electrophysiology
Evoked Potentials - physiology
Functional Laterality - physiology
Fundamental and applied biological sciences. Psychology
Hippocampus
Hippocampus - physiology
Male
Matching to Sample
Mental Recall - physiology
Neurology
Neurons
Neurons - physiology
Orientation - physiology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rats
Rats, Sprague-Dawley
Rodents
Synaptic Transmission - physiology
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Summary:Hippocampal CA1 and CA3 neurons were recorded in rats performing a delayed-match-to-sample (DMTS) task. Complex spike cells showed significant firing peaks following sample and match responses and during delivery of water reward. Individual cells were classified into 4 subtypes according to the presence or absence of firing in each of these 3 phases. There were significant differences in delay interval firing among the 4 subtypes, but firing during the delay did not predict the correct response: 34% of the cells showed a linear change in firing during the delay. Further analyses revealed significant lever position firing biases in approximately 70% of the cells tested irrespective of subtype. The complexity of firing correlates of the neurons recorded in this DMTS task suggests that the hippocampus divides specific aspects of the performance demands of the task across different cell subtypes, which together provide sufficient information to resolve the matching-to-sample problem on any given trial.
ISSN:0735-7044
1939-0084
DOI:10.1037/0735-7044.107.5.715