Protein Kinase C Activation Modulates Reversible Increase in Cortical Blood–Brain Barrier Permeability and Tight Junction Protein Expression during Hypoxia and Posthypoxic Reoxygenation

Hypoxia (Hx) is a component of many disease states including stroke. Ischemic stroke occurs when there is a restriction of cerebral blood flow and oxygen to part of the brain. During the ischemic, and subsequent reperfusion phase of stroke, blood–brain barrier (BBB) integrity is lost with tight junc...

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Bibliographic Details
Published in:Journal of cerebral blood flow and metabolism 2010-11, Vol.30 (11), p.1847-1859
Main Authors: Willis, Colin L, Meske, Diana S, Davis, Thomas P
Format: Article
Language:English
Subjects:
Animals
Benzophenanthridines - pharmacology
Biological and medical sciences
Blood-Brain Barrier - drug effects
Blood-Brain Barrier - metabolism
Cerebral Cortex - blood supply
Endothelial Cells - enzymology
Endothelial Cells - pathology
Enzyme Activation
Female
Hypoxia - metabolism
Hypoxia - pathology
Injuries of the nervous system and the skull. Diseases due to physical agents
Isoenzymes - metabolism
Medical sciences
Microvessels - metabolism
Nerve Tissue Proteins - metabolism
Neurology
Original
Oxygen - metabolism
Permeability
Protein Kinase C - metabolism
Rats
Rats, Sprague-Dawley
Signal Transduction
Tight Junctions - metabolism
Time Factors
Traumas. Diseases due to physical agents
Vascular diseases and vascular malformations of the nervous system
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