Chemical shift imaging in the head and neck at 3T: Initial results

Purpose To determine the optimal method to correct air and tissue susceptibility differences in the head and neck to allow proton (1H) chemical shift imaging (CSI) to be performed at 3T. Materials and Methods Shimming protocols (iterative, first‐order, and second‐order) and perfluorocarbon (PFC) pad...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 2010-11, Vol.32 (5), p.1248-1254
Main Authors: Yeung, David K.W., Fong, Kwan-Ying, Chan, Queenie C.C., King, Ann D.
Format: Article
Language:English
Subjects:
Adult
Aged
chemical shift imaging
choline
Choline - analysis
Female
Head - pathology
head and neck cancer
Head and Neck Neoplasms - chemistry
Head and Neck Neoplasms - diagnosis
Humans
Image Processing, Computer-Assisted
Lymphatic Metastasis
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Male
Middle Aged
Neck - pathology
Phantoms, Imaging
Proton MR spectroscopy
shimming
susceptibility
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Summary:Purpose To determine the optimal method to correct air and tissue susceptibility differences in the head and neck to allow proton (1H) chemical shift imaging (CSI) to be performed at 3T. Materials and Methods Shimming protocols (iterative, first‐order, and second‐order) and perfluorocarbon (PFC) pads were evaluated using water peak linewidth measurements obtained from single‐voxel magnetic resonance spectroscopy (MRS) on a head and neck phantom. After optimization of the technique, CSI was then tested on 14 patients with head and neck tumors. Results Second‐order shimming (water peak linewidth, 4.6 Hz) performed significantly (P < 0.001) better than first‐order (16.5 Hz) and iterative shimming (18 Hz) and the water peak linewidth was significantly reduced using PFC pads (P < 0.001). Using second‐order shimming and PFC pads, CSI was successful in 10 patients with nodal metastases (n = 8) and benign tumors (n = 2) and unsuccessful in four patients with primary tumors along the aerodigestive tract. Conclusion Proton CSI can be successfully performed in the head and neck using second‐order shimming and PFC pads to correct air and tissue susceptibility differences. CSI was more successfully performed on nodal metastases, while CSI for primary tumors along the aerodigestive tract remains a challenge. J. Magn. Reson. Imaging 2010;32:1248–1254. © 2010 Wiley‐Liss, Inc.
ISSN:1053-1807
1522-2586
DOI:10.1002/jmri.22365