Human Corticotropin-Releasing Hormone (hCRH) Test: Sex and Age Differences in Plasma ACTH and Cortisol Responses and their Reproducibility in Healthy Adults

The effectiveness and safety of MCI-028, a synthetic human corticotropin-releasing hormone (hCRH), as a diagnostic drug were examined in 65 healthy male and 24 healthy female adult volunteers. Mean maximum concentrations of plasma ACTH and cortisol after intraveneous administration of 100 μg of MCI-...

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Bibliographic Details
Published in:Endocrine Journal 1993, Vol.40(5), pp.571-579
Main Authors: TANAKA, KOSHI, SHIMIZU, NAOKATA, IMURA, HIROO, FUKATA, JUNICHI, HIBI, ITSURO, TANAKA, TOSHIAKI, NAKAGAWA, SHOICHI, FUJIEDA, KENJI, TAKEBE, KAZUO, YOSHINAGA, KAORU, TAKAKURA, KINTOMO, SUWA, SEIZO, TACHIBANA, KATSUHIKO, KATO, KIYOHIKO, YOSHIMI, TERUYA, MIURA, KIYOSHI, KUWAYAMA, AKIO, OTA, ZENSUKE, KATO, YUZURU, SAITO, SHIRO, TAKAHARA, JIRO, HASHIMOTO, KOZO, NAWATA, HAJIME, MATSUKURA, SHIGERU, YANAIHARA, NOBORU
Format: Article
Language:English
Subjects:
ACTH
Adrenal Cortex Function Tests
Adrenocorticotropic Hormone - blood
Adrenocorticotropic Hormone - metabolism
Adult
Age Factors
Biological and medical sciences
Body Temperature - drug effects
Corticotropin-Releasing Hormone - adverse effects
Corticotropin-Releasing Hormone - pharmacology
Diagnostic drug
Endocrinology
Female
Flushing - chemically induced
hCRH
Hemodynamics - drug effects
Humans
Hydrocortisone - blood
Hydrocortisone - metabolism
Hypothalamic-pituitary-adrenocortical system
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Pituitary Function Tests
Pituitary-Adrenal System - drug effects
Pituitary-Adrenal System - metabolism
Reference Values
Reproducibility of Results
Secretory Rate
Sex Factors
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Description
Summary:The effectiveness and safety of MCI-028, a synthetic human corticotropin-releasing hormone (hCRH), as a diagnostic drug were examined in 65 healthy male and 24 healthy female adult volunteers. Mean maximum concentrations of plasma ACTH and cortisol after intraveneous administration of 100 μg of MCI-028 were 3.0 and 2.0 times their basal concentrations, respectively, and there were no significant age or sex differences in the responses. Good reproducibility was observed in the responses in 59 male subjects who received a second administration after 1 to 2 weeks. Although slight adverse reactions such as mild and transient hot flushing were observed, these were not serious.
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.40.571