Comparative activity of memory-modulating neuropeptides before and after electric shock in white rats

Neuropeptides are shown to exert a powerful influence on mnestic processes. They actively eliminate phenomena of electric-shock amnesia, the strongest agent here being arginine vasopressin, while derivatives of oxytocin, enkephalin, and melanostatin are active to a lesser degree. The selective effec...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 1985-05, Vol.15 (3), p.240-246
Main Authors: Medvedev, V I, Bakharev, V D, Kaurov, O A
Format: Article
Language:English
Subjects:
adrenocorticotropic hormone
Adrenocorticotropic Hormone - pharmacology
Amnesia - drug therapy
Animals
Arginine Vasopressin - pharmacology
Avoidance Learning - drug effects
enkephalin, leucine
Enkephalin, Leucine - pharmacology
ESB
Humans
long term memory
Memory - drug effects
MSH Release-Inhibiting Hormone - analogs & derivatives
MSH Release-Inhibiting Hormone - pharmacology
Oxytocin - analogs & derivatives
Oxytocin - pharmacology
Peptide Fragments - pharmacology
Peptides - pharmacology
Rats
vasopressin, arginine
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Summary:Neuropeptides are shown to exert a powerful influence on mnestic processes. They actively eliminate phenomena of electric-shock amnesia, the strongest agent here being arginine vasopressin, while derivatives of oxytocin, enkephalin, and melanostatin are active to a lesser degree. The selective effect on primary learning (ACTH4-7 and Leu-enkephalin) and on the consolidation and restoration of memory (vasopressin and oxytocin), and the presence of only antiamnestic properties (analog of the melanocyte-inhibiting factor) - all this suggests different mechanisms of action of these agents. Memory modulators act more strongly upon activated systems that are already prepared to receive the signal. A promising object for future study as a therapeutic antiamnestic factor is the long-term memory modulator arginine vasopressin.
ISSN:0097-0549
1573-899X
DOI:10.1007/BF01182994