Double‐blind comparative study of droperidol, granisetron and granisetron plus dexamethasone as prophylactic anti‐emetic therapy in patients undergoing abdominal, gynaecological, breast or otolaryngological surgery

In this double‐blind study the clinical efficacy of a single pre‐operative intravenous dose of droperidol 1.25 mg (137 patients), granisetron 1 mg (130 patients) and granisetron 1 mg plus dexamethasone 5 mg (130 patients) was investigated for the prevention of postoperative nausea and vomiting after...

Full description

Saved in:
Bibliographic Details
Published in:Anaesthesia 1999-11, Vol.54 (11), p.1059-1068
Main Authors: Janknegt, R., Pinckaers, J. W. M., Rohof, M. H. C., Ausems, M. E. M., Arbouw, M. E. L., Van Der Velden, R. W., Brouwers, J. R. B. J.
Format: Article
Language:English
Subjects:
Adult
Anesthesia, General - adverse effects
Antiemetics - administration & dosage
Biological and medical sciences
Dexamethasone - administration & dosage
Digestive system
Double-Blind Method
Droperidol - administration & dosage
Drug Therapy, Combination
Female
Granisetron - administration & dosage
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Pharmacology
droperidol, granisetron, dexamethasone
Postoperative Nausea and Vomiting - prevention & control
Surgery
miscellaneous
Treatment Outcome
Vomiting
nausea, incidence, anti‐emetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this double‐blind study the clinical efficacy of a single pre‐operative intravenous dose of droperidol 1.25 mg (137 patients), granisetron 1 mg (130 patients) and granisetron 1 mg plus dexamethasone 5 mg (130 patients) was investigated for the prevention of postoperative nausea and vomiting after gynaecological surgery, breast surgery, abdominal surgery and ear, nose and throat surgery. The incidence of nausea in the first 24 h postoperatively was 52% in the droperidol group, 48% in the granisetron group and 34% with the combination, respectively. Both granisetron and granisetron/dexamethasone performed better than droperidol in their effects on vomiting or combined nausea and vomiting (incidence in the first 24 h 22%, 18% and 42%, respectively). The number of emetic episodes during the 5‐day study period was significantly higher in the droperidol group (198) than in the granisetron (73) or combination group (78).
ISSN:0003-2409
1365-2044
DOI:10.1046/j.1365-2044.1999.01075.x