Successful decolonization of meticillin-resistant Staphylococcus aureus in paediatric patients with cystic fibrosis (CF) using a three-step protocol

Summary Meticillin-resistant Staphylococcus aureus (MRSA) is recognized as a bacterial pathogen in patients with cystic fibrosis (CF) although its clinical effects can be variable. The aim of this study was to evaluate the efficacy of a three-step decolonization protocol for MRSA (Belfast CF MRSA de...

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Bibliographic Details
Published in:The Journal of hospital infection 2007-03, Vol.65 (3), p.231-236
Main Authors: Macfarlane, M, Leavy, A, McCaughan, J, Fair, R, Reid, A.J.M
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial diseases
Biological and medical sciences
Cystic fibrosis
Errors of metabolism
Human bacterial diseases
Infection control
Infectious Disease
Infectious diseases
Lung infection
Medical sciences
Metabolic diseases
Miscellaneous hereditary metabolic disorders
MRSA
Paediatric
Pharmacology. Drug treatments
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
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Summary:Summary Meticillin-resistant Staphylococcus aureus (MRSA) is recognized as a bacterial pathogen in patients with cystic fibrosis (CF) although its clinical effects can be variable. The aim of this study was to evaluate the efficacy of a three-step decolonization protocol for MRSA (Belfast CF MRSA decolonization protocol). Of the 17 paediatric patients treated during the five years of the study, eight (47%) were successfully decolonized following one five-day course of oral rifampicin and fusidic acid. The success rate increased to 12 (71%) patients after a second five-day oral treatment course in the 11 patients who remained culture positive at the end of the first treatment cycle. In a further four patients, clearance was achieved with a course of intravenous teicoplanin, increasing the decolonization rate to 16 of 17 patients (94%). These results compare favourably with other published studies and show that MRSA decolonization can be successful in a high proportion of paediatric CF patients.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2006.10.011