Loading…
Hepatitis B Virus Activation among Central Africans Infected with Human Immunodeficiency Virus (HIV) Type 1: Pre-s2 Antigen Is Predominantly Expressed in HIV Infection
To evaluate the impact of human immunodeficiency virus (HIV) type 1 on the natural history of hepatitis B virus (HBV) infection, sera from Central Africans with and without antibodies to HIV were examined for HBV markers of ongoing replication, recovery from infection, and reactivation or reinfectio...
Saved in:
| Published in: | The Journal of infectious diseases 1994-03, Vol.169 (3), p.628-632 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c414t-ef7d2207143ed3530a9519318f6af859a934d3a6aa08417eec884879debc56d13 |
|---|---|
| cites | |
| container_end_page | 632 |
| container_issue | 3 |
| container_start_page | 628 |
| container_title | The Journal of infectious diseases |
| container_volume | 169 |
| creator | Kashala, Oscar Mubikayi, Luamba Kayembe, Kalambayi Mukeba, Prudence Essex, Max |
| description | To evaluate the impact of human immunodeficiency virus (HIV) type 1 on the natural history of hepatitis B virus (HBV) infection, sera from Central Africans with and without antibodies to HIV were examined for HBV markers of ongoing replication, recovery from infection, and reactivation or reinfection. The prevalence of HBV infection and HBV surface antigen (HBsAg) was similar for HIV-positive and -negative persons. AIDS patients were more likely to be HBsAg positive and have markers of viral replication. Unlike pre-surface (pre-s) 1 antigen (Ag), which did not differ significantly with respect to HIV infection, pre-s2Ag was more common among HIV-positive persons than among HIV-negative ones and was more common among AIDS patients than among HIV-positive asymptomatic carriers. HIV-positive persons had more markers consistent with HBV reactivation and lower levels of antibody to HBsAg. |
| doi_str_mv | 10.1093/infdis/169.3.628 |
| format | article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_76445379</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>30113789</jstor_id><sourcerecordid>30113789</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-ef7d2207143ed3530a9519318f6af859a934d3a6aa08417eec884879debc56d13</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhSMEKkNhzwbJC4RgkakdJ_5hNx0VMqISFSojxMZynZvikjjBdqDzRLwmHk0YlqyudM8537V8suw5wUuCJT2zrm1sOCNMLumSFeJBtiAV5TljhD7MFhgXRU6ElI-zJyHcYYxLyvhJdiJIJTCVi-x3DaOONtqAztHW-imglYn2Z9oNDul-cLdoDS563aFV663RLqCNa8FEaNAvG7-heuq1Q5u-n9zQQGuNBWd2M-x1vdm-Qde7ERB5i6485KFAKxftLaRM2G-aobdOu9jt0MX96CGERLYOpeR8KT3lafao1V2AZ_M8zT6_u7he1_nlx_eb9eoyNyUpYw4tb4oCc1JSaGhFsZYVkZSIlulWVFJLWjZUM62xKAkHMEKUgssGbkzFGkJPs1cH7uiHHxOEqHobDHSddjBMQXFWlumD5X-NqZJKSimSER-Mxg8heGjV6G2v_U4RrPYlqkOJ-4SiKpWYIi9m9nTTQ3MMzK0l_eWs62B013rtTAL8tZVYMCnIP8xdiIM_yhQTQrnYY_KDbkOE-6Ou_XfFOOWVqr98VXx7Lj59WFfqiv4BkEC_aA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16959998</pqid></control><display><type>article</type><title>Hepatitis B Virus Activation among Central Africans Infected with Human Immunodeficiency Virus (HIV) Type 1: Pre-s2 Antigen Is Predominantly Expressed in HIV Infection</title><source>Oxford University Press Archive</source><creator>Kashala, Oscar ; Mubikayi, Luamba ; Kayembe, Kalambayi ; Mukeba, Prudence ; Essex, Max</creator><creatorcontrib>Kashala, Oscar ; Mubikayi, Luamba ; Kayembe, Kalambayi ; Mukeba, Prudence ; Essex, Max</creatorcontrib><description>To evaluate the impact of human immunodeficiency virus (HIV) type 1 on the natural history of hepatitis B virus (HBV) infection, sera from Central Africans with and without antibodies to HIV were examined for HBV markers of ongoing replication, recovery from infection, and reactivation or reinfection. The prevalence of HBV infection and HBV surface antigen (HBsAg) was similar for HIV-positive and -negative persons. AIDS patients were more likely to be HBsAg positive and have markers of viral replication. Unlike pre-surface (pre-s) 1 antigen (Ag), which did not differ significantly with respect to HIV infection, pre-s2Ag was more common among HIV-positive persons than among HIV-negative ones and was more common among AIDS patients than among HIV-positive asymptomatic carriers. HIV-positive persons had more markers consistent with HBV reactivation and lower levels of antibody to HBsAg.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/169.3.628</identifier><identifier>PMID: 8158039</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Africa, Central - epidemiology ; AIDS ; AIDS-Related Opportunistic Infections - epidemiology ; AIDS-Related Opportunistic Infections - microbiology ; AIDS/HIV ; Antibodies ; Antigens ; Biological and medical sciences ; Biomarkers ; Concise Communications ; Developed countries ; Female ; Hepatitis antigens ; Hepatitis B - complications ; Hepatitis B - epidemiology ; Hepatitis B - microbiology ; Hepatitis B Surface Antigens - biosynthesis ; Hepatitis B virus ; Hepatitis B virus - physiology ; Hepatocellular carcinoma ; HIV ; HIV infections ; HIV-1 ; human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infections ; Infectious diseases ; Male ; Medical sciences ; Pregnancy ; Prevalence ; Protein Precursors - biosynthesis ; Tropical medicine ; Viral diseases ; Viral hepatitis ; Virus Activation</subject><ispartof>The Journal of infectious diseases, 1994-03, Vol.169 (3), p.628-632</ispartof><rights>Copyright 1994 The University of Chicago</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-ef7d2207143ed3530a9519318f6af859a934d3a6aa08417eec884879debc56d13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4086981$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8158039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kashala, Oscar</creatorcontrib><creatorcontrib>Mubikayi, Luamba</creatorcontrib><creatorcontrib>Kayembe, Kalambayi</creatorcontrib><creatorcontrib>Mukeba, Prudence</creatorcontrib><creatorcontrib>Essex, Max</creatorcontrib><title>Hepatitis B Virus Activation among Central Africans Infected with Human Immunodeficiency Virus (HIV) Type 1: Pre-s2 Antigen Is Predominantly Expressed in HIV Infection</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>To evaluate the impact of human immunodeficiency virus (HIV) type 1 on the natural history of hepatitis B virus (HBV) infection, sera from Central Africans with and without antibodies to HIV were examined for HBV markers of ongoing replication, recovery from infection, and reactivation or reinfection. The prevalence of HBV infection and HBV surface antigen (HBsAg) was similar for HIV-positive and -negative persons. AIDS patients were more likely to be HBsAg positive and have markers of viral replication. Unlike pre-surface (pre-s) 1 antigen (Ag), which did not differ significantly with respect to HIV infection, pre-s2Ag was more common among HIV-positive persons than among HIV-negative ones and was more common among AIDS patients than among HIV-positive asymptomatic carriers. HIV-positive persons had more markers consistent with HBV reactivation and lower levels of antibody to HBsAg.</description><subject>Adult</subject><subject>Africa, Central - epidemiology</subject><subject>AIDS</subject><subject>AIDS-Related Opportunistic Infections - epidemiology</subject><subject>AIDS-Related Opportunistic Infections - microbiology</subject><subject>AIDS/HIV</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Concise Communications</subject><subject>Developed countries</subject><subject>Female</subject><subject>Hepatitis antigens</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - microbiology</subject><subject>Hepatitis B Surface Antigens - biosynthesis</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - physiology</subject><subject>Hepatocellular carcinoma</subject><subject>HIV</subject><subject>HIV infections</subject><subject>HIV-1</subject><subject>human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Prevalence</subject><subject>Protein Precursors - biosynthesis</subject><subject>Tropical medicine</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Virus Activation</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAUhSMEKkNhzwbJC4RgkakdJ_5hNx0VMqISFSojxMZynZvikjjBdqDzRLwmHk0YlqyudM8537V8suw5wUuCJT2zrm1sOCNMLumSFeJBtiAV5TljhD7MFhgXRU6ElI-zJyHcYYxLyvhJdiJIJTCVi-x3DaOONtqAztHW-imglYn2Z9oNDul-cLdoDS563aFV663RLqCNa8FEaNAvG7-heuq1Q5u-n9zQQGuNBWd2M-x1vdm-Qde7ERB5i6485KFAKxftLaRM2G-aobdOu9jt0MX96CGERLYOpeR8KT3lafao1V2AZ_M8zT6_u7he1_nlx_eb9eoyNyUpYw4tb4oCc1JSaGhFsZYVkZSIlulWVFJLWjZUM62xKAkHMEKUgssGbkzFGkJPs1cH7uiHHxOEqHobDHSddjBMQXFWlumD5X-NqZJKSimSER-Mxg8heGjV6G2v_U4RrPYlqkOJ-4SiKpWYIi9m9nTTQ3MMzK0l_eWs62B013rtTAL8tZVYMCnIP8xdiIM_yhQTQrnYY_KDbkOE-6Ou_XfFOOWVqr98VXx7Lj59WFfqiv4BkEC_aA</recordid><startdate>19940301</startdate><enddate>19940301</enddate><creator>Kashala, Oscar</creator><creator>Mubikayi, Luamba</creator><creator>Kayembe, Kalambayi</creator><creator>Mukeba, Prudence</creator><creator>Essex, Max</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19940301</creationdate><title>Hepatitis B Virus Activation among Central Africans Infected with Human Immunodeficiency Virus (HIV) Type 1: Pre-s2 Antigen Is Predominantly Expressed in HIV Infection</title><author>Kashala, Oscar ; Mubikayi, Luamba ; Kayembe, Kalambayi ; Mukeba, Prudence ; Essex, Max</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-ef7d2207143ed3530a9519318f6af859a934d3a6aa08417eec884879debc56d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Africa, Central - epidemiology</topic><topic>AIDS</topic><topic>AIDS-Related Opportunistic Infections - epidemiology</topic><topic>AIDS-Related Opportunistic Infections - microbiology</topic><topic>AIDS/HIV</topic><topic>Antibodies</topic><topic>Antigens</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Concise Communications</topic><topic>Developed countries</topic><topic>Female</topic><topic>Hepatitis antigens</topic><topic>Hepatitis B - complications</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - microbiology</topic><topic>Hepatitis B Surface Antigens - biosynthesis</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - physiology</topic><topic>Hepatocellular carcinoma</topic><topic>HIV</topic><topic>HIV infections</topic><topic>HIV-1</topic><topic>human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Prevalence</topic><topic>Protein Precursors - biosynthesis</topic><topic>Tropical medicine</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Virus Activation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kashala, Oscar</creatorcontrib><creatorcontrib>Mubikayi, Luamba</creatorcontrib><creatorcontrib>Kayembe, Kalambayi</creatorcontrib><creatorcontrib>Mukeba, Prudence</creatorcontrib><creatorcontrib>Essex, Max</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kashala, Oscar</au><au>Mubikayi, Luamba</au><au>Kayembe, Kalambayi</au><au>Mukeba, Prudence</au><au>Essex, Max</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis B Virus Activation among Central Africans Infected with Human Immunodeficiency Virus (HIV) Type 1: Pre-s2 Antigen Is Predominantly Expressed in HIV Infection</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1994-03-01</date><risdate>1994</risdate><volume>169</volume><issue>3</issue><spage>628</spage><epage>632</epage><pages>628-632</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>To evaluate the impact of human immunodeficiency virus (HIV) type 1 on the natural history of hepatitis B virus (HBV) infection, sera from Central Africans with and without antibodies to HIV were examined for HBV markers of ongoing replication, recovery from infection, and reactivation or reinfection. The prevalence of HBV infection and HBV surface antigen (HBsAg) was similar for HIV-positive and -negative persons. AIDS patients were more likely to be HBsAg positive and have markers of viral replication. Unlike pre-surface (pre-s) 1 antigen (Ag), which did not differ significantly with respect to HIV infection, pre-s2Ag was more common among HIV-positive persons than among HIV-negative ones and was more common among AIDS patients than among HIV-positive asymptomatic carriers. HIV-positive persons had more markers consistent with HBV reactivation and lower levels of antibody to HBsAg.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>8158039</pmid><doi>10.1093/infdis/169.3.628</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1994-03, Vol.169 (3), p.628-632 |
| issn | 0022-1899 1537-6613 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76445379 |
| source | Oxford University Press Archive |
| subjects | Adult Africa, Central - epidemiology AIDS AIDS-Related Opportunistic Infections - epidemiology AIDS-Related Opportunistic Infections - microbiology AIDS/HIV Antibodies Antigens Biological and medical sciences Biomarkers Concise Communications Developed countries Female Hepatitis antigens Hepatitis B - complications Hepatitis B - epidemiology Hepatitis B - microbiology Hepatitis B Surface Antigens - biosynthesis Hepatitis B virus Hepatitis B virus - physiology Hepatocellular carcinoma HIV HIV infections HIV-1 human immunodeficiency virus 1 Human viral diseases Humans Infections Infectious diseases Male Medical sciences Pregnancy Prevalence Protein Precursors - biosynthesis Tropical medicine Viral diseases Viral hepatitis Virus Activation |
| title | Hepatitis B Virus Activation among Central Africans Infected with Human Immunodeficiency Virus (HIV) Type 1: Pre-s2 Antigen Is Predominantly Expressed in HIV Infection |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T13%3A41%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hepatitis%20B%20Virus%20Activation%20among%20Central%20Africans%20Infected%20with%20Human%20Immunodeficiency%20Virus%20(HIV)%20Type%201:%20Pre-s2%20Antigen%20Is%20Predominantly%20Expressed%20in%20HIV%20Infection&rft.jtitle=The%20Journal%20of%20infectious%20diseases&rft.au=Kashala,%20Oscar&rft.date=1994-03-01&rft.volume=169&rft.issue=3&rft.spage=628&rft.epage=632&rft.pages=628-632&rft.issn=0022-1899&rft.eissn=1537-6613&rft.coden=JIDIAQ&rft_id=info:doi/10.1093/infdis/169.3.628&rft_dat=%3Cjstor_proqu%3E30113789%3C/jstor_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c414t-ef7d2207143ed3530a9519318f6af859a934d3a6aa08417eec884879debc56d13%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=16959998&rft_id=info:pmid/8158039&rft_jstor_id=30113789&rfr_iscdi=true |