Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

Many tumors express tumor-specific antigens capable of being presented to CD8$^+$ T cells by major histocompatibility complex (MHC) class I molecules. Antigen presentation models predict that the tumor cell itself should present these antigens to T cells. However, when conditions for the priming of...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1994-05, Vol.264 (5161), p.961-965
Main Authors: Alex Y. C. Huang, Golumbek, Paul, Ahmadzadeh, Mojgan, Jaffee, Elizabeth, Pardoll, Drew, Levitsky, Hyam
Format: Article
Language:English
Subjects:
Animals
Antigen presenting cells
Antigen-antibody reactions, antigen-antibody complexes, antibody-complement and others. Study of affinity. Antigen presentation
Antigen-Presenting Cells - immunology
Antigens
Antigens, Neoplasm - immunology
Biological and medical sciences
Bone Marrow - immunology
Bone Marrow Cells
Bones
Chimeras
Colonic Neoplasms - immunology
Epitopes
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Granulocyte-Macrophage Colony-Stimulating Factor - genetics
Granulocyte-Macrophage Colony-Stimulating Factor - immunology
H-2 Antigens - immunology
Histocompatibility Antigens Class I - immunology
Immune response
Melanoma, Experimental - immunology
MHC antibodies
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Molecular immunology
Neoplasm antigens
Nucleocapsid Proteins
Nucleoproteins
Splenocytes
T lymphocytes
T-Lymphocytes, Cytotoxic - immunology
Tumor antigens
Tumor Cells, Cultured
Tumors
Vaccination
Viral Core Proteins - immunology
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Summary:Many tumors express tumor-specific antigens capable of being presented to CD8$^+$ T cells by major histocompatibility complex (MHC) class I molecules. Antigen presentation models predict that the tumor cell itself should present these antigens to T cells. However, when conditions for the priming of tumor-specific responses were examined in mice, no detectable presentation of MHC class I-restricted tumor antigens by the tumor itself was found. Rather, tumor antigens were exclusively presented by host bone marrow-derived cells. Thus, MHC class I-restricted antigens are efficiently transferred in vivo to bone marrow-derived antigen-presenting cells, which suggests that human leukocyte antigen matching may be less critical in the application of tumor vaccines than previously thought.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.7513904