HTLV-I proviral DNA in umbilical cord blood of babies born to carrier mothers

Human T-lymphotropic virus type l (HTLV-l) in cord blood raises the possibility of intrauterine transmission as an alternative pathway to transmission via breast milk. However, none of 7 children with HTLV-l proviral DNA positive cord blood had seroconverted by 24–48 months. Contamination of cord bl...

Full description

Saved in:
Bibliographic Details
Published in:The Lancet (British edition) 1994-05, Vol.343 (8909), p.1326-1327
Main Authors: Katamine, S., Moriuchi, R., Yamamoto, T., Terada, K., Miyamoto, T., Eguchi, K., Tsuji, Y., Yamabe, T., Hino, S.
Format: Article
Language:English
Subjects:
AIDS/HIV
Babies
Blood
Breast Feeding
Breast milk
Carrier State
Deoxyribonucleic acid
DNA
DNA, Viral - blood
Female
Fetal Blood - microbiology
HTLV-I Infections - transmission
Human T-lymphotropic virus 1 - genetics
Human T-lymphotropic virus 1 - isolation & purification
Humans
Infant, Newborn
Infections
Leukemia
Medical research
Pregnancy
Proviruses
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Human T-lymphotropic virus type l (HTLV-l) in cord blood raises the possibility of intrauterine transmission as an alternative pathway to transmission via breast milk. However, none of 7 children with HTLV-l proviral DNA positive cord blood had seroconverted by 24–48 months. Contamination of cord blood by maternal blood was precluded on the basis of viral load and lgA concentration. Thus cord blood proviral DNA is not a hallmark of intrauterine infection. Moreover, none of the cord blood samples of 9 formula-fed children later confirmed to be infected was positive for HTLV-l, indicating that intrauterine infection is not likely candidate as an alternative pathway. Lancet 1994; 343: 1326–27
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(94)92469-4