Effects of dobutamine on oxygen transport and consumption in the adult respiratory distress syndrome

• Published in: Intensive care medicine 1994-02, Vol.20 (2), p.130-137
• Main Authors: KRACHMAN, S. L, LODATO, R. F, MORICE, R, GUTIERREZ, G, DANTZKER, D. R
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biological and medical sciences; Blood Gas Analysis; Cardiotonic agents; Cardiovascular system; Dobutamine - pharmacology; Dose-Response Relationship, Drug; Female; Hemodynamics - drug effects; Humans; Infection - blood; Infection - drug therapy; Infection - etiology; Infection - physiopathology; Infusions, Intravenous; Lactates - blood; Lactic Acid; Male; Medical sciences; Middle Aged; Oxygen - blood; Oxygen - pharmacokinetics; Oxygen Consumption - drug effects; Pharmacology. Drug treatments; Prospective Studies; Respiratory Distress Syndrome, Adult - blood; Respiratory Distress Syndrome, Adult - drug therapy; Respiratory Distress Syndrome, Adult - etiology; Respiratory Distress Syndrome, Adult - physiopathology; Tissue Distribution
• ISSN: 0342-4642; 1432-1238
• DOI: 10.1007/BF01707668

To determine if oxygen consumption (VO2) in patients with adult respiratory distress syndrome (ARDS) is dependent on, and thus limited by, oxygen transport (TO2) rather than O2 demand. Prospective study. Intensive care unit of a tertiary referral center. 12 patients with ARDS and sepsis syndrome. Routine intensive care unit monitoring including pulmonary and radial artery catheters. Dobutamine was used to increase cardiac output, thereby directly varying TO2 under conditions of constant O2 demand. After baseline measurements of TO2 and VO2, dobutamine was infused intravenously at progressively increasing doses of 5, 10, 15 and 20 micrograms/kg/min and measurements of TO2 and VO2 were repeated after 30 min at each dose. Dobutamine increased TO2 in 8 of the 12 patients, by 29% at 5 micrograms/kg/min and by 45% (net) at 10 micrograms/kg/min, but not at higher doses. In these 8 patients dobutamine also increased VO2 by 15% at 5 micrograms/kg/min, but did not further increase VO2 at higher doses. There was no correlation between baseline blood lactate concentration and the response of either TO2 or VO2 to dobutamine. In some but not all patients with ARDS and sepsis syndrome, short-term infusion of low-dose dobutamine can increase both TO2 and VO2. Achievement of a TO2-independent level of VO2 could not be convincingly demonstrated in any individual patient. The response of TO2 and VO2 to dobutamine could not be predicted from baseline blood lactate concentration. Determination of the impact on patient outcome of a more prolonged infusion of dobutamine requires further study.