Patients with renal cancer have a larger proportion of high-density blood monocytes with increased lucigenin-enhanced chemiluminescence

The production of oxygen metabolites is probably important in cancer cell killing. The production of the superoxide anion, O2-, can be measured by lucigenin-enhanced chemiluminescence (Cl). Previous studies have shown that whole-blood lucigenin-enhanced Cl is increased in cancer patients and that th...

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Bibliographic Details
Published in:Inflammation 1994-02, Vol.18 (1), p.99-105
Main Authors: Trulson, A, Nilsson, S, Brekkan, E, Venge, P
Format: Article
Language:English
Subjects:
Acridines
Adult
Aged
Aged, 80 and over
Blood Cell Count
Carcinoma, Renal Cell - blood
Female
Humans
Luminescent Measurements
Male
Middle Aged
Monocytes
Oxidation-Reduction
Superoxides - metabolism
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Summary:The production of oxygen metabolites is probably important in cancer cell killing. The production of the superoxide anion, O2-, can be measured by lucigenin-enhanced chemiluminescence (Cl). Previous studies have shown that whole-blood lucigenin-enhanced Cl is increased in cancer patients and that this increase is related to blood monocyte activity. The present investigation confirmed these findings and showed that whole-blood lucigenin-enhanced Cl was elevated in 17 patients with renal cell adenocarcinoma (P < 0.001). The activity of the monocytes was studied more in detail, whereby monocytes were separated into different populations based upon differences in densities, i.e., high-density and low-density monocytes. The cancer patients had a significantly larger proportion of high-density monocytes (P < 0.05) than controls. The lucigenin-enhanced Cl of purified high-density monocytes in controls was significantly higher than that of low-density monocytes (P < 0.01). The authors conclude that the increase in the lucigenin-enhanced Cl of whole blood observed in cancer patients may partly reflect the increased activity of a larger proportion of high-density monocytes in these patients.
ISSN:0360-3997
1573-2576
DOI:10.1007/BF01534602