Effect of avian influenza virus infection on the phagocytic function of systemic phagocytes and pulmonary macrophages of turkeys

The effects of avian influenza virus (AIV) infection on systemic phagocytes and pulmonary macrophages of turkeys were studied. There was a significant increase (P 0.0001) in oxidative burst in systemic phagocytes of AIV-inoculated turkeys on 2, 4, 6, and 8 days postinoculation (PI), as measured by c...

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Bibliographic Details
Published in:Avian diseases 1994-01, Vol.38 (1), p.93-102
Main Authors: Kodihalli, S, Sivanandan, V, Nagaraja, K.V, Shaw, D, Halvorson, D.A
Format: Article
Language:English
Subjects:
Alveolar macrophages
Animals
Cell Separation
Cells, Cultured
Chemiluminescence
Chick Embryo
DINDON
Escherichia coli
FAGOCITOS
HISTOPATHOLOGIE
HISTOPATOLOGIA
Infections
Influenza A virus
Influenza A virus - growth & development
Influenza A virus - isolation & purification
Influenza in Birds - pathology
Influenza in Birds - physiopathology
INFLUENZAVIRUS AVIAIRE
Luminescent Measurements
Lung - pathology
Lungs
MACROFAGOS
MACROPHAGE
Macrophages
Macrophages, Alveolar - physiology
Mucous Membrane - pathology
PAVO
PHAGOCYTE
Phagocytes
Phagocytes - physiology
Phagocytosis
POUMON
PROPIEDADES ANTIMICROBIANAS
PROPRIETE ANTIMICROBIENNE
PULMONES
REPONSE IMMUNITAIRE
RESPUESTA INMUNOLOGICA
Trachea
Trachea - pathology
TRACHEE
TRAQUEA
Turkeys
VIRUS DE LA INFLUENZA AVIAR
Viruses
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Summary:The effects of avian influenza virus (AIV) infection on systemic phagocytes and pulmonary macrophages of turkeys were studied. There was a significant increase (P 0.0001) in oxidative burst in systemic phagocytes of AIV-inoculated turkeys on 2, 4, 6, and 8 days postinoculation (PI), as measured by chemiluminescence. There was also a significant increase (P 0.02) in oxidative burst in pulmonary macrophages on day 4 PI. The chemiluminescence response was depressed on 6, 8, and 10 days PI in AIV-inoculated turkeys compared with controls. The increase in oxidative response in both systemic phagocytes and pulmonary macrophages correlated with the peak virus titer in the lungs and trachea of AIV-inoculated turkeys. Bacterial killing by pulmonary macrophages from AIV-inoculated turkeys was reduced on days 6 and 10 PI compared with uninoculated controls. Histopathological changes in trachea were more pronounced on day 6 PI in AIV-inoculated turkeys; no significant changes were detected in the lungs. These data indicate that compromised functional capacity of pulmonary macrophages predisposes turkeys to secondary bacterial infections
ISSN:0005-2086
1938-4351
DOI:10.2307/1591842