Platelet-derived growth factor (PDGF) receptors in the developing mouse optic pathway

The molecules which control the patterns of cell division, growth, and precise interconnections characteristic of the central nervous system still remain largely unidentified. The protein platelet-derived growth factor (PDGF) has been shown to mediate interactions among glial cells in vitro. More re...

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Bibliographic Details
Published in:Visual neuroscience 1994-01, Vol.11 (1), p.33-40
Main Authors: Hutchins, James B., Zhang, Xiaorong
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blotting, Western
Brain - embryology
Brain - metabolism
Embryonic and Fetal Development
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
Mice
Mice, Inbred C57BL
Optic chiasm
Optic Chiasm - embryology
Optic Chiasm - metabolism
Optic nerve
Optic Nerve - embryology
Optic Nerve - metabolism
Platelet-Derived Growth Factor - metabolism
Proto-oncogenes
Receptors, Platelet-Derived Growth Factor - metabolism
Retina
Retinal Ganglion Cells - metabolism
Tyrosine kinases
Vertebrates: nervous system and sense organs
Visual Pathways - metabolism
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Summary:The molecules which control the patterns of cell division, growth, and precise interconnections characteristic of the central nervous system still remain largely unidentified. The protein platelet-derived growth factor (PDGF) has been shown to mediate interactions among glial cells in vitro. More recent evidence has indicated that PDGF may also be involved in controlling communication between neurons and glial cells and among neurons. The presence of receptors for PDGF on neurons of the developing nervous system is an essential piece of evidence in this chain of events. Ganglion cells are labeled with antibodies to PDGF receptor only during the period of active process outgrowth. These findings suggest that PDGF is used as a mediator of intercellular signaling during neuronal development.
ISSN:0952-5238
1469-8714
DOI:10.1017/S0952523800011081