Hepatitis C Virus (HCV) Viremia in Human Immunodeficiency Virus-Seronegative and -Seropositive Patients with Indeterminate HCV Recombinant Immunoblot Assay

Positivity of recombinant immunoblot assay (RIBA) for detection of antibodies to hepatitis C virus (anti-HCV) is usually associated with HCV viremia. The significance of an indeterminate RIBA result, defined by reactivity to only one HCV antigen, is unclear. Whether anti-human immunodeficiency virus...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 1994-08, Vol.170 (2), p.433-435
Main Authors: Marcellin, Patrick, Martinot-Peignoux, Michèle, Elias, Alida, Branger, Michel, Courtois, Françoise, Level, Régine, Erlinger, Serge, Benhamou, Jean Pierre
Format: Article
Language:English
Subjects:
AIDS/HIV
Alanine Transaminase - blood
Antibodies
Antigens
Antigens, Viral - immunology
Concise Communications
Enzyme-Linked Immunosorbent Assay
Hepacivirus
Hepacivirus - genetics
Hepacivirus - immunology
Hepatitis Antibodies - blood
Hepatitis C - complications
Hepatitis C Antibodies
Hepatitis C Antigens
hepatitis C virus
HIV Seronegativity
HIV Seropositivity - complications
human immunodeficiency virus
Humans
Immunoblotting
Infections
Physiological immunosuppression
Polymerase Chain Reaction
Reactivity
Recombinant Proteins - immunology
RNA
RNA, Viral - blood
Viremia
Viremia - complications
Viruses
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Positivity of recombinant immunoblot assay (RIBA) for detection of antibodies to hepatitis C virus (anti-HCV) is usually associated with HCV viremia. The significance of an indeterminate RIBA result, defined by reactivity to only one HCV antigen, is unclear. Whether anti-human immunodeficiency virus (HIV)-negative or -positive subjects with an indeterminate RIBA have HCV viremia detectable by polymerase chain reaction was investigated. An indeterminate RIBA was found in 48 (15%) of 318 anti-HIV-negative and 38 (23%) of 167 anti-HIV-positive subjects (P < .05). Clinical stage was IV-C-1 or IV-C-2 in 82% of those anti-HIV-positive. HCV viremia was found more frequently in anti-HIV-positive (89%) than in anti-HIV-negative subjects (50%) with an indeterminate RIBA (P < .05). These results suggest an impaired anti-HCV response associated with HIV infection.
ISSN:0022-1899