Chromosomal gains and losses in uveal melanomas detected by comparative genomic hybridization

Eleven uveal melanomas were analyzed using comparative genomic hybridization (CGH). The most abundant genetic changes were loss of chromosome 3, overrepresentation of 6p, loss of 6q, and multiplication of 8q. The smallest overrepresented regions on 6p and 8q were 6pter-->p21 and 8q24-->qter, r...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1994-07, Vol.54 (14), p.3817-3823
Main Authors: SPEICHER, M. R, PRESCHER, G, DU MANOIR, S, JAUCH, A, HORSTHEMKE, B, BORNFELD, N, BECHER, R, CREMER, T
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Chromosome Aberrations
Chromosome Banding
Chromosome Deletion
Female
Humans
Male
Medical sciences
Melanoma - genetics
Middle Aged
Nucleic Acid Hybridization
Ophthalmology
Skin Neoplasms - genetics
Tumors and pseudotumors of the eye, orbit, eyelid, lacrimal apparatus
Uveal Neoplasms - genetics
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Summary:Eleven uveal melanomas were analyzed using comparative genomic hybridization (CGH). The most abundant genetic changes were loss of chromosome 3, overrepresentation of 6p, loss of 6q, and multiplication of 8q. The smallest overrepresented regions on 6p and 8q were 6pter-->p21 and 8q24-->qter, respectively. Several additional gains and losses of chromosome segments were repeatedly observed, the most frequent one being loss of 9p (three cases). Monosomy 3 appeared to be a marker for ciliary body involvement. CGH data were compared with the results of chromosome banding. Some alterations, e.g., gains of 6p and losses of 6q, were observed with higher frequencies after CGH, while others, e.g., 9p deletions, were detected only by CGH. The data suggest some similarities of cytogenetic alterations between cutaneous and uveal melanoma. In particular, the 9p deletions are of interest due to recent reports about the location of a putative tumor-suppressor gene for cutaneous malignant melanoma in this region.
ISSN:0008-5472
1538-7445