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STRUCTURE-ACTIVITY RELATIONSHIP AMONG POLYHYDRO DERIVATIVES OF TYLOSIN

Tetra-, hexa-and octahydro derivatives of tylosin were prepared by the reduction of the conjugated double bond and carbonyl groups. Hydrogenation of the diene did not change the in vitro antimicrobial activity of compounds, while reduction of carbonyls causes small or complete loss of activity.

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Published in:	Journal of antibiotics 1994/05/25, Vol.47(5), pp.581-587
Main Authors:	NARANDJA, AMALIA, ŠUŠKOVIC, BOZIDAR, KELNERIC, ZELJKO, DJOKIC, SLOBODAN
Format:	Article
Language:	English
Subjects:	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Structure-Activity Relationship Tylosin - analogs & derivatives Tylosin - chemistry Tylosin - pharmacology
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cited_by	cdi_FETCH-LOGICAL-c637t-50ba0bbc79837facdd0bea5ea62fbb042595d23870c23445c3e79036141323e33
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container_end_page	587
container_issue	5
container_start_page	581
container_title	Journal of antibiotics
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creator	NARANDJA, AMALIA ŠUŠKOVIC, BOZIDAR KELNERIC, ZELJKO DJOKIC, SLOBODAN
description	Tetra-, hexa-and octahydro derivatives of tylosin were prepared by the reduction of the conjugated double bond and carbonyl groups. Hydrogenation of the diene did not change the in vitro antimicrobial activity of compounds, while reduction of carbonyls causes small or complete loss of activity.
doi_str_mv	10.7164/antibiotics.47.581
format	article
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identifier	ISSN: 0021-8820
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subjects	Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Magnetic Resonance Spectroscopy Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Structure-Activity Relationship Tylosin - analogs & derivatives Tylosin - chemistry Tylosin - pharmacology
title	STRUCTURE-ACTIVITY RELATIONSHIP AMONG POLYHYDRO DERIVATIVES OF TYLOSIN
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