Comparative in-vitro activity of biapenem and other carbapenems against Haemophilus influenzae isolates with known resistance mechanisms to ampicillin

Ampicillin resistance in Haemophilus influenzae may be caused by beta -lactamase production or by intrinsic mechanisms entailing target modification and/or impermeability. beta -Lactamase-mediated resistance can be overcome with newer-generation cephalosporins or with inhibitor combinations but intr...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1994-04, Vol.33 (4), p.861-865
Main Authors: Yeo, Siew-Fah, Livermore, David M.
Format: Article
Language:English
Subjects:
Ampicillin Resistance
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacterial Typing Techniques
Biological and medical sciences
Carbapenems - pharmacology
Culture Media
Haemophilus influenzae
Haemophilus influenzae - drug effects
Haemophilus influenzae - enzymology
Haemophilus influenzae - metabolism
Indoles - metabolism
Medical sciences
Microbial Sensitivity Tests
Ornithine Decarboxylase - biosynthesis
Pharmacology. Drug treatments
Thienamycins - pharmacology
Urease - biosynthesis
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Summary:Ampicillin resistance in Haemophilus influenzae may be caused by beta -lactamase production or by intrinsic mechanisms entailing target modification and/or impermeability. beta -Lactamase-mediated resistance can be overcome with newer-generation cephalosporins or with inhibitor combinations but intrinsic resistance compromises these compounds as well as ampicillin. However, previous studies indicated that the imipenem and meropenem retained almost full activity against intrinsically ampicillin-resistant H. influenzae. Moreover, laboratory transformants of ampicillin-resistant isolates and ampicillin-selected laboratory mutants both showed smaller increases in resistance to imipenem and meropenem than to other beta -lactams. These observations suggested that intrinsic resistance to carbapenems was largely dissociated from that to other beta -lactams. The present study re-examined this hypothesis, using a large recent collection of isolates. Biapenem (L-627) was tested in addition to the carbapenems studied previously.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/33.4.861