EFFECT OF ISOFLURANE ON BRONCHOMOTOR TONE IN MAN

Twenty patients were anaesthetized with thio-pentone, the trachea intubated and the lungs ventilated with 70% nitrous oxide and oxygen. Normocapnia was maintained and, following control measurements of the specific conductance of the lower airways (s.Glaw), either 1.7% isoflurane or 1.3% halothane w...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1986-01, Vol.58 (1), p.24-28
Main Authors: HENEGHAN, C.P.H., BERGMAN, N.A., JORDAN, C., LEHANE, J.R., CATLEY, D.M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Airway Resistance - drug effects
Anesthetics. Neuromuscular blocking agents
Biological and medical sciences
Bronchi - drug effects
Expiratory Reserve Volume
Female
Halothane - pharmacology
Humans
Isoflurane - pharmacology
Male
Medical sciences
Methyl Ethers - pharmacology
Middle Aged
Muscle Tonus - drug effects
Neuropharmacology
Pharmacology. Drug treatments
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Summary:Twenty patients were anaesthetized with thio-pentone, the trachea intubated and the lungs ventilated with 70% nitrous oxide and oxygen. Normocapnia was maintained and, following control measurements of the specific conductance of the lower airways (s.Glaw), either 1.7% isoflurane or 1.3% halothane was added to the inspired gas mixture, 10 patients receiving each drug. s.Glaw was measured repeatedly during the next 30 min. There was a tendency for s.Glaw to increase indicating a reduction in broncho-motor tone during the administration of isoflurane, the effect approaching statistical significance. The administration of halothane was associated with a significant increase in s.Glaw. There was a statistically significant increase in the expiratory reserve volume, and a decrease in mean respiratory resistance over the tidal range in both groups. These results indicate that isoflurane does not cause an increase in bronchomotor tone, and may have a tendency to decrease it. This suggests that the previously reported increase of respiratory resistance during isoflurane anaesthesia resulted from a reduction in lung volume, rathesr than a change in bronchomotor tone.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/58.1.24