ENHANCED RETINAL AND OPTIC NERVE EXCITABILITY ASSOCIATED WITH DEMYELINATION IN MICE INFECTED WITH SEMLIKI FOREST VIRUS

The physiological effects of Semliki Forest virus (SFV) induced demyelination on the visual system of mice have been examined by recording electroretinograms (ERGs) and the spike activity in the retinal ganglion cell axons in control and SFV-infected mice The amplitudes of ERGs evoked by a single fl...

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Bibliographic Details
Published in:Brain (London, England : 1878) England : 1878), 1986-02, Vol.109 (1), p.15-30
Main Authors: TANSEY, E. M., ALLEN, T. G. J., IKEDA, HISAKO
Format: Article
Language:English
Subjects:
Animals
Arboviroses
Biological and medical sciences
Demyelinating Diseases - physiopathology
Electroretinography
Experimental viral diseases and models
Human viral diseases
Infectious diseases
Male
Medical sciences
Mice
Mice, Inbred Strains
Miscellaneous
Optic Nerve Diseases - physiopathology
Retinal Diseases - physiopathology
Semliki forest virus
Togaviridae Infections - physiopathology
Tropical medicine
Tropical viral diseases
Viral diseases
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Summary:The physiological effects of Semliki Forest virus (SFV) induced demyelination on the visual system of mice have been examined by recording electroretinograms (ERGs) and the spike activity in the retinal ganglion cell axons in control and SFV-infected mice The amplitudes of ERGs evoked by a single flash in the dark-adapted eyes of the SFV infected mice were abnormally enhanced, whereas flicker ERGs were slightly depressed. This hyperactivity was also seen in the ganglion cell axonal discharge. Both visually evoked and spontaneous activity recorded from the optic tract fibres of the infected mice were characterized by rhythmic oscillatory bursts of firing. Similar patterns were seen only very rarely in the evoked activity recorded from control mice. We suggest that this oscillatory firing might be a functional correlate of the types of ‘positive symptoms’ reported by multiple sclerosis patients with optic neuritis.
ISSN:0006-8950
1460-2156
DOI:10.1093/brain/109.1.15