Idiopathic deep vein thrombosis in an apparently healthy patient as a premonitory sign of occult cancer

An association between migratory venous thrombosis or acute pulmonary embolism and occult cancer has been previously suggested. The relationship between the commoner deep venous thrombosis (DVT) in an otherwise healthy individual and occult cancer is not known. The incidence of cancer in 35 otherwis...

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Bibliographic Details
Published in:Cancer 1986-05, Vol.57 (9), p.1846-1849
Main Authors: Aderka, Dan, Brown, Abraham, Zelikovski, Avigdor, Pinkhas, Jack
Format: Article
Language:English
Subjects:
Age Factors
Aged
Biological and medical sciences
Eosinophils
Female
Follow-Up Studies
General aspects
Hemoglobins - analysis
Hip
Humans
Leukocyte Count
Male
Medical sciences
Middle Aged
Neoplasms - diagnosis
Neoplasms - pathology
Pulmonary Embolism - complications
Risk
Thrombophlebitis - complications
Thrombophlebitis - pathology
Time Factors
Tumors
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Summary:An association between migratory venous thrombosis or acute pulmonary embolism and occult cancer has been previously suggested. The relationship between the commoner deep venous thrombosis (DVT) in an otherwise healthy individual and occult cancer is not known. The incidence of cancer in 35 otherwise healthy patients with idiopathic DVT (group A) was compared to 48 patients with DVT due to a known etiology, excluding cancer (group B). In 12 patients of group A (34%), a diagnosis of cancer was established 4–68 months after the DVT episode, compared to 2 patients of group B (4%) (P = 0.001). The origin of the earliest discovered cancer (up to 8 months) was the reproductive organs (ovary, endometrium, prostate, breast), while the later discovered malignancies were of colon, pancreas, lung and a lymphoma. At the initial idiopathic DVT episode, patients found subsequently to have cancer, were older than the control group (P
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19860501)57:9<1846::AID-CNCR2820570925>3.0.CO;2-3