Thermodynamic Proton-Ligand and Metal-Ligand Stability Constants of Some Drugs

The thermodynamic proton-ligand (pKa) and metal ligand stability constants of clioquinol, clofibrate, nitrofurazone, and tetracycline with Cu2+, Zn2+, Mn2+, Mg2+, and Ca2+ have been determined at 35°C in 50% ethanol-water media. An empirical pH correction for mixed-aqueous media has been applied. Th...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1986-02, Vol.75 (2), p.190-192
Main Authors: Agrawal, Y.K., Patel, D.R.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Buffers
Chelating Agents - analysis
Drug Stability
General pharmacology
Ligands
Medical sciences
Metals - analysis
Nitrofurazone - analysis
Pharmacology. Drug treatments
Physicochemical properties. Structure-activity relationships
Protons
Tetracycline - analysis
Thermodynamics
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Summary:The thermodynamic proton-ligand (pKa) and metal ligand stability constants of clioquinol, clofibrate, nitrofurazone, and tetracycline with Cu2+, Zn2+, Mn2+, Mg2+, and Ca2+ have been determined at 35°C in 50% ethanol-water media. An empirical pH correction for mixed-aqueous media has been applied. The metal-ligand stability constants were determined by following the Bjerrum Calvin titration technique as applied by Agrawal to mixed-aqueous solvents. The effect of the basicity of the ligand and the order of stability constants is discussed. The stability constants of the divalent metals follow the order: Cu2+>Zn2+>Mn2+>Mg2+>Ca2+ with all the drugs.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600750219